Volifen
Generic Name
Diclofenac Diethylamine 1.16% w/w (equivalent to Diclofenac Sodium 1% w/w) Gel
Manufacturer
Healthcare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| volifen 1 w gel | ৳ 100.00 | N/A |
Description
Overview of the medicine
Volifen-1-W Gel is a non-steroidal anti-inflammatory drug (NSAID) applied topically to relieve pain and inflammation associated with musculoskeletal conditions.
Uses & Indications
Dosage
Adults
Apply 2 to 4 grams of gel (approx. 2.5-5 cm strip) to the affected area 3-4 times daily and rub gently into the skin.
Elderly
Same as adult dosage.
Renal_impairment
No specific dosage adjustment required for topical application, as systemic absorption is minimal.
How to Take
For external use only. Apply a small amount of gel to the affected area and gently rub it into the skin. Wash hands thoroughly after application unless the hands are the treated area.
Mechanism of Action
Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. When applied topically, it exerts its local anti-inflammatory and analgesic effects.
Pharmacokinetics
Onset
Pain relief usually within 30-60 minutes.
Excretion
Primarily renal (approximately 60%) and biliary/fecal (approximately 30-40%).
Half life
Approximately 1-2 hours in plasma after systemic absorption, but terminal half-life at the site of action might be longer due to tissue binding.
Absorption
Systemic absorption is low (typically <6%), but varies based on application area, skin integrity, and duration. Peak plasma concentrations are significantly lower than with oral administration.
Metabolism
Primarily hepatic via hydroxylation and glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to diclofenac, aspirin, or other NSAIDs.
- Application to open wounds, infected skin, or eczema.
- Third trimester of pregnancy.
- Children under 12 years of age (consult physician).
Drug Interactions
Oral NSAIDs
Concomitant use with oral NSAIDs may increase the risk of systemic side effects.
Anticoagulants
Caution with anticoagulants as diclofenac may enhance their effects, although unlikely with topical application.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose with topical diclofenac gel is unlikely due to low systemic absorption. If accidentally ingested, symptomatic and supportive treatment should be given.
Pregnancy & Lactation
Use in the first and second trimesters of pregnancy only if clearly needed and after consulting a doctor. Contraindicated in the third trimester due to potential fetal harm (premature closure of ductus arteriosus). Use during lactation only if necessary, as small amounts may pass into breast milk; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to diclofenac, aspirin, or other NSAIDs.
- Application to open wounds, infected skin, or eczema.
- Third trimester of pregnancy.
- Children under 12 years of age (consult physician).
Drug Interactions
Oral NSAIDs
Concomitant use with oral NSAIDs may increase the risk of systemic side effects.
Anticoagulants
Caution with anticoagulants as diclofenac may enhance their effects, although unlikely with topical application.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose with topical diclofenac gel is unlikely due to low systemic absorption. If accidentally ingested, symptomatic and supportive treatment should be given.
Pregnancy & Lactation
Use in the first and second trimesters of pregnancy only if clearly needed and after consulting a doctor. Contraindicated in the third trimester due to potential fetal harm (premature closure of ductus arteriosus). Use during lactation only if necessary, as small amounts may pass into breast milk; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of topical diclofenac in treating various musculoskeletal pain conditions and osteoarthritis. Studies often show comparable efficacy to oral NSAIDs with fewer systemic side effects.
Lab Monitoring
- No specific routine lab monitoring required for topical diclofenac gel due to minimal systemic absorption.
Doctor Notes
- Advise patients on proper application technique and to wash hands thoroughly.
- Emphasize avoiding application on damaged skin, open wounds, or mucous membranes.
- Counsel patients on potential photosensitivity and to protect treated areas from sun exposure.
Patient Guidelines
- Do not apply to open wounds or irritated skin.
- Avoid contact with eyes and mucous membranes.
- Do not cover the treated area with occlusive bandages.
- Wash hands after application.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose.
Driving Precautions
Volifen-1-W Gel is not expected to affect the ability to drive or operate machinery, as systemic absorption is minimal.
Lifestyle Advice
- Maintain adequate hydration.
- For musculoskeletal pain, consider gentle exercises and stretches as advised by a physiotherapist.
- Avoid prolonged exposure to direct sunlight on the treated area to minimize photosensitivity.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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