Voltid
Generic Name
Diclofenac Sodium 50 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| voltid 50 mg tablet | ৳ 0.60 | N/A |
Description
Overview of the medicine
Voltid 50 mg tablet contains Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID), used for the relief of pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
Usually 50 mg two to three times daily, or as directed by a physician. Maximum recommended daily dose is 150 mg.
Elderly
Lower doses may be required due to increased sensitivity or impaired renal function. Monitor renal function closely.
Renal_impairment
Use with caution. Reduced dosage may be necessary. Monitor renal function.
How to Take
Take the tablet orally with food or milk to minimize gastrointestinal discomfort. Swallow the tablet whole; do not crush, chew, or break it.
Mechanism of Action
Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, leading to a reduction in prostaglandin synthesis. This reduction in prostaglandins mediates its anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Within 30 minutes to 1 hour.
Excretion
Approximately 60% excreted in urine as metabolites and less than 1% as unchanged drug; approximately 35% excreted in bile/feces as metabolites.
Half life
Approximately 1-2 hours for parent compound.
Absorption
Rapidly and completely absorbed orally, though absorption rate may be decreased by food.
Metabolism
Primarily hepatic metabolism via cytochrome P450 enzymes (CYP2C9 and CYP2C8) to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to diclofenac or other NSAIDs (e.g., aspirin)
- •Active gastrointestinal bleeding or peptic ulcer
- •Severe renal or hepatic impairment
- •Severe heart failure
- •Third trimester of pregnancy
- •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium concentrations.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal adverse events.
Diuretics and ACE Inhibitors
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive treatment, gastric lavage, and activated charcoal. Dialysis is unlikely to be beneficial.
Pregnancy & Lactation
Pregnancy Category C in first and second trimesters; Category D in third trimester. Avoid in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution in first and second trimesters only if potential benefit outweighs risk. Not recommended during breastfeeding due to excretion in breast milk and potential adverse effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Generally approved by regulatory bodies (e.g., FDA)
Patent Status
Patent expired for generic formulation
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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