Vonocab
Generic Name
Vonoprazan 20 mg tablet
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vonocab 20 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Vonocab 20 mg tablet contains Vonoprazan, a potassium-competitive acid blocker (PCAB) used to treat acid-related disorders of the stomach and esophagus by suppressing gastric acid secretion.
Uses & Indications
Dosage
Adults
Gastric/Duodenal Ulcer: 20 mg once daily for 6-8 weeks. Reflux Esophagitis: 20 mg once daily for 4-8 weeks. H. pylori eradication: 20 mg twice daily for 7 days in combination with antibiotics.
Elderly
No specific dosage adjustment required based on age, but caution is advised due to potential comorbidities.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment. For severe impairment, caution is advised.
How to Take
Take the tablet orally, preferably in the morning, with or without food. Do not chew or crush the tablet.
Mechanism of Action
Vonoprazan reversibly inhibits the H+, K+-ATPase enzyme (proton pump) in the gastric parietal cells by competing with potassium ions. This leads to a potent and prolonged suppression of gastric acid secretion.
Pharmacokinetics
Onset
Within hours of administration, acid suppression is achieved.
Excretion
Mainly via urine and feces.
Half life
Approximately 7-9 hours (terminal elimination half-life).
Absorption
Rapidly absorbed, reaching peak plasma concentrations within 1.5 to 2 hours.
Metabolism
Primarily metabolized in the liver by CYP3A4 and to a lesser extent by CYP2B6, CYP2C19, CYP2D6.
Side Effects
Contraindications
- Hypersensitivity to Vonoprazan or any component of the formulation
- Concomitant use with Atazanavir, Nelfinavir, or Rilpivirine (due to reduced absorption of antivirals)
Drug Interactions
Digoxin
Increased absorption of digoxin, requiring monitoring of digoxin levels.
Warfarin
Monitor INR, as vonoprazan may affect warfarin metabolism.
Methotrexate
Possible increase in methotrexate exposure.
Atazanavir, Nelfinavir, Rilpivirine
Reduced absorption of these antiviral drugs, leading to decreased efficacy. Concomitant use is contraindicated.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Treatment should be symptomatic and supportive. Vonoprazan is not effectively removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown if Vonoprazan is excreted in human milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Vonoprazan or any component of the formulation
- Concomitant use with Atazanavir, Nelfinavir, or Rilpivirine (due to reduced absorption of antivirals)
Drug Interactions
Digoxin
Increased absorption of digoxin, requiring monitoring of digoxin levels.
Warfarin
Monitor INR, as vonoprazan may affect warfarin metabolism.
Methotrexate
Possible increase in methotrexate exposure.
Atazanavir, Nelfinavir, Rilpivirine
Reduced absorption of these antiviral drugs, leading to decreased efficacy. Concomitant use is contraindicated.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Treatment should be symptomatic and supportive. Vonoprazan is not effectively removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown if Vonoprazan is excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved by health authorities in various countries
Patent Status
Varies by country; original patent held by Takeda
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Vonoprazan in various acid-related disorders, including head-to-head studies against PPIs.
Lab Monitoring
- No routine specific lab monitoring is usually required. For long-term use, vitamin B12 levels might be considered.
Doctor Notes
- Vonoprazan offers rapid and sustained acid suppression, often useful for patients unresponsive to PPIs.
- Be mindful of potential drug interactions, especially with certain antivirals.
- Counsel patients on adherence and lifestyle modifications.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine abruptly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
No known effects on driving ability, but if you experience dizziness or visual disturbances, avoid driving or operating machinery.
Lifestyle Advice
- Avoid spicy and fatty foods if they trigger your symptoms.
- Maintain a healthy weight.
- Avoid smoking and excessive alcohol consumption.
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