Vonopa
Generic Name
Vonoprazan 20 mg tablet
Manufacturer
Local Pharmaceutical Company (e.g., Incepta Pharmaceuticals)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vonopa 20 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Vonopa 20 mg tablet contains Vonoprazan, a potassium-competitive acid blocker (P-CAB) used to treat acid-related disorders like gastric ulcers, duodenal ulcers, reflux esophagitis, and for H. pylori eradication. It provides rapid and sustained acid suppression.
Uses & Indications
Dosage
Adults
For gastric ulcer, duodenal ulcer, reflux esophagitis: 20 mg once daily. For H. pylori eradication: 20 mg twice daily with appropriate antibiotics.
Elderly
No specific dosage adjustment needed unless severe hepatic or renal impairment.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment. Use with caution in severe renal impairment.
How to Take
Take orally, once daily, with or without food. For H. pylori eradication, take as directed with antibiotics.
Mechanism of Action
Vonoprazan is a potassium-competitive acid blocker (P-CAB) that reversibly inhibits the H+/K+-ATPase proton pump in gastric parietal cells, thereby suppressing gastric acid secretion. Unlike PPIs, it does not require acid activation and binds to the pump independently of its activation state.
Pharmacokinetics
Onset
Within hours for significant acid suppression.
Excretion
Excreted predominantly in urine (major) and feces (minor).
Half life
Approximately 7-9 hours (terminal elimination half-life).
Absorption
Rapidly absorbed after oral administration, peak plasma concentration (Cmax) reached within 1.5-2 hours. Bioavailability is high.
Metabolism
Primarily metabolized in the liver mainly by CYP3A4, with minor contributions from CYP2B6, CYP2C19, and CYP2D6.
Side Effects
Contraindications
- Hypersensitivity to Vonoprazan or any component of the formulation.
- Co-administration with atazanavir or nelfinavir (for HIV treatment).
Drug Interactions
Clopidogrel
Potential for reduced antiplatelet effect, though less significant than with some PPIs.
Methotrexate
Increased plasma levels of methotrexate, especially with high doses.
Drugs dependent on gastric pH
Vonoprazan reduces gastric acid, potentially affecting absorption of drugs like ketoconazole, itraconazole, atazanavir, nelfinavir, iron salts.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for Vonoprazan overdose. In case of overdose, symptomatic and supportive treatment should be administered. Hemodialysis is unlikely to be effective due to high protein binding.
Pregnancy & Lactation
Pregnancy Category B. Animal studies show no evidence of harm to the fetus, but human data are limited. Use only if clearly needed. It is not known whether vonoprazan is excreted in human milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to Vonoprazan or any component of the formulation.
- Co-administration with atazanavir or nelfinavir (for HIV treatment).
Drug Interactions
Clopidogrel
Potential for reduced antiplatelet effect, though less significant than with some PPIs.
Methotrexate
Increased plasma levels of methotrexate, especially with high doses.
Drugs dependent on gastric pH
Vonoprazan reduces gastric acid, potentially affecting absorption of drugs like ketoconazole, itraconazole, atazanavir, nelfinavir, iron salts.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for Vonoprazan overdose. In case of overdose, symptomatic and supportive treatment should be administered. Hemodialysis is unlikely to be effective due to high protein binding.
Pregnancy & Lactation
Pregnancy Category B. Animal studies show no evidence of harm to the fetus, but human data are limited. Use only if clearly needed. It is not known whether vonoprazan is excreted in human milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved in various countries including Japan, USA, and Bangladesh.
Patent Status
Patented by Takeda/Otsuka, but generic versions are available in some markets.
Clinical Trials
Vonoprazan has undergone extensive clinical trials demonstrating its efficacy and safety for various acid-related disorders and H. pylori eradication, showing superior or non-inferior results compared to conventional PPIs.
Lab Monitoring
- Liver function tests (especially with long-term use)
- Magnesium levels (for prolonged therapy)
Doctor Notes
- Assess patient's complete medical history before prescribing.
- Consider potential drug interactions, especially with pH-dependent drugs or those metabolized by CYP3A4.
- Monitor patients for long-term adverse effects if therapy is prolonged.
Patient Guidelines
- Take Vonopa exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly without consulting your doctor.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Vonoprazan is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or other side effects that impair concentration, avoid driving.
Lifestyle Advice
- Avoid trigger foods (spicy, fatty, acidic foods) that worsen your acid reflux.
- Maintain a healthy lifestyle, including regular exercise and stress management.
- Avoid smoking and excessive alcohol consumption, as these can exacerbate stomach acid problems.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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