Vortiox
Generic Name
Vortioxetine
Manufacturer
Lundbeck
Country
Denmark
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vortiox 5 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Vortioxetine is an antidepressant used to treat major depressive disorder (MDD) in adults. It acts as a serotonin reuptake inhibitor and also has direct receptor activity.
Uses & Indications
Dosage
Adults
Initial dose is 10 mg once daily, may be increased to a maximum of 20 mg once daily, or decreased to 5 mg once daily based on response and tolerability.
Elderly
No specific dose adjustment needed based on age alone, but caution with potential for reduced CYP2D6 metabolism.
Renal_impairment
No dose adjustment needed.
How to Take
Oral administration, with or without food. Swallow the tablet whole.
Mechanism of Action
Vortioxetine is a multimodal antidepressant that acts as a serotonin (5-HT) reuptake inhibitor, 5-HT3 and 5-HT7 receptor antagonist, and 5-HT1A receptor agonist. This results in modulation of neurotransmitter activity in the brain, particularly serotonin, which is believed to contribute to its antidepressant effects.
Pharmacokinetics
Onset
Antidepressant effects may be seen within 2 weeks, but full effect often takes 4-6 weeks.
Excretion
Approximately 59% excreted in urine and 26% in feces.
Half life
Approximately 66 hours (range 57-73 hours).
Absorption
Well absorbed after oral administration, peak plasma concentrations reached within 7-11 hours.
Metabolism
Primarily metabolized in the liver by CYP2D6, CYP3A4/5, CYP2C19, CYP2C9, CYP2A6, CYP2B6, and CYP2E1 enzymes, with CYP2D6 being the primary enzyme.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping MAOIs
- Hypersensitivity to vortioxetine or any excipients
Drug Interactions
MAOIs
Increased risk of serotonin syndrome.
SSRIs/SNRIs
Increased risk of serotonin syndrome.
Strong CYP inducers (e.g., rifampicin, carbamazepine, phenytoin)
May decrease vortioxetine exposure, requiring dose adjustment.
Strong CYP2D6 inhibitors (e.g., bupropion, fluoxetine, paroxetine, quinidine)
May increase vortioxetine exposure, requiring dose adjustment.
Storage
Store at room temperature (below 30°C), protect from moisture and light. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, abdominal discomfort, generalized pruritus, somnolence, and dizziness. Management is primarily supportive care. Consider activated charcoal.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is unknown if vortioxetine is excreted in human milk.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping MAOIs
- Hypersensitivity to vortioxetine or any excipients
Drug Interactions
MAOIs
Increased risk of serotonin syndrome.
SSRIs/SNRIs
Increased risk of serotonin syndrome.
Strong CYP inducers (e.g., rifampicin, carbamazepine, phenytoin)
May decrease vortioxetine exposure, requiring dose adjustment.
Strong CYP2D6 inhibitors (e.g., bupropion, fluoxetine, paroxetine, quinidine)
May increase vortioxetine exposure, requiring dose adjustment.
Storage
Store at room temperature (below 30°C), protect from moisture and light. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, abdominal discomfort, generalized pruritus, somnolence, and dizziness. Management is primarily supportive care. Consider activated charcoal.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is unknown if vortioxetine is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 36 months
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Patent protected (for innovator, generic versions available in some markets)
Clinical Trials
Extensive clinical trials have demonstrated efficacy in the treatment of Major Depressive Disorder, with improvements in depressive symptoms and cognitive function. Trials have also investigated safety and tolerability profiles.
Lab Monitoring
- Monitor for hyponatremia, especially in elderly patients on diuretics.
- Monitor for worsening depression and suicidality, especially at the beginning of treatment or after dose changes.
Doctor Notes
- Monitor patients for signs of serotonin syndrome, especially when co-administered with other serotonergic agents.
- Advise patients on the importance of gradual discontinuation to minimize withdrawal symptoms.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking abruptly without consulting your doctor, as withdrawal symptoms may occur.
- Report any unusual mood changes or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or somnolence. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that Vortioxetine therapy does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid alcohol consumption while on this medication.
- Engage in stress-reducing activities.
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