Winfax
Generic Name
Cefixime 125 mg/5 ml Suspension
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| winfax 125 mg suspension | ৳ 198.00 | N/A |
Description
Overview of the medicine
Winfax 125 mg Suspension contains Cefixime, a third-generation cephalosporin antibiotic. It is used to treat various bacterial infections in children.
Uses & Indications
Dosage
Adults
Typically for pediatric use. Adult dosage (tablet form) is usually 400 mg once daily.
Elderly
No specific dosage adjustment for elderly unless renal impairment is present. Monitor renal function.
Renal_impairment
Dosage adjustment is necessary based on creatinine clearance. For CrCl 21-60 mL/min: 75% of standard dose. For CrCl < 20 mL/min: 50% of standard dose.
How to Take
Administer orally, with or without food. Shake the bottle well before each use. Use the provided measuring spoon or cup for accurate dosing.
Mechanism of Action
Cefixime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-6 hours.
Excretion
Primarily excreted via renal and biliary routes, with about 50% excreted unchanged in urine.
Half life
Average plasma half-life is 3-4 hours.
Absorption
Approximately 40-50% absorbed orally.
Metabolism
Limited hepatic metabolism.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or penicillins.
Drug Interactions
Nifedipine
May increase cefixime absorption.
Carbamazepine
Increased carbamazepine levels may occur.
Warfarin and other anticoagulants
May increase the anticoagulant effect, requiring close monitoring of INR.
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard after 7-14 days (check specific product label). Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment is recommended. Gastric lavage may be indicated. Hemodialysis or peritoneal dialysis is not effective in removing cefixime.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy and lactation only if clearly needed and under medical supervision.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or penicillins.
Drug Interactions
Nifedipine
May increase cefixime absorption.
Carbamazepine
Increased carbamazepine levels may occur.
Warfarin and other anticoagulants
May increase the anticoagulant effect, requiring close monitoring of INR.
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard after 7-14 days (check specific product label). Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment is recommended. Gastric lavage may be indicated. Hemodialysis or peritoneal dialysis is not effective in removing cefixime.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy and lactation only if clearly needed and under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 24 months from manufacturing date for dry powder, and 7-14 days after reconstitution when stored as directed.
Availability
Pharmacies, hospitals
Approval Status
Approved by health authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety for treating various bacterial infections in pediatric and adult populations.
Lab Monitoring
- For prolonged therapy, periodic assessment of renal, hepatic, and hematopoietic functions is advisable.
- Coombs' test may become positive.
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent antibiotic resistance.
- Counsel parents on proper reconstitution and administration of the suspension.
- Advise on monitoring for signs of superinfection or allergic reactions.
Patient Guidelines
- Complete the entire prescribed course of medication, even if symptoms improve.
- Shake the suspension well before each use.
- Measure the dose accurately using the provided device.
- Do not save unused medicine for future infections.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain good hygiene to prevent the spread of infections.
- Drink plenty of fluids unless advised otherwise by your doctor.
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