Winfax
Generic Name
Cefixime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| winfax 250 mg tablet | ৳ 25.00 | ৳ 150.00 |
Description
Overview of the medicine
Winfax 250 mg Tablet contains Cefixime, a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It is effective against various gram-positive and gram-negative bacteria.
Uses & Indications
Dosage
Adults
The usual adult dose is 400 mg daily, given as a single dose or in two divided doses of 200 mg every 12 hours. For 250 mg tablets, it can be 250 mg twice daily. Duration of treatment varies from 7 to 14 days depending on the infection.
Elderly
No dosage adjustment is generally required for elderly patients unless there is severe renal impairment.
Renal_impairment
Dosage adjustment is recommended for patients with creatinine clearance less than 60 mL/min. For CrCl 21-60 mL/min, 300 mg daily. For CrCl <20 mL/min, 200 mg daily.
How to Take
Winfax tablets can be taken orally with or without food. It is recommended to take it at approximately the same time each day to maintain consistent drug levels.
Mechanism of Action
Cefixime is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding prevents the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations are generally achieved within 2-6 hours after oral administration.
Excretion
Excreted primarily by the kidneys, with about 50% of the absorbed dose excreted unchanged in the urine within 24 hours. Small amounts are also excreted in bile and feces.
Half life
The plasma half-life is typically 3-4 hours in individuals with normal renal function.
Absorption
Approximately 40-50% orally absorbed. Food may delay absorption but does not significantly alter the extent of absorption.
Metabolism
Cefixime is not extensively metabolized in the body. Little or no active metabolites have been identified.
Side Effects
Contraindications
- Patients with known hypersensitivity to Cefixime, other cephalosporins, or to any of the excipients.
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
Concurrent use may increase Cefixime Cmax and AUC.
Carbamazepine
Cefixime may increase carbamazepine levels when co-administered.
Warfarin and Anticoagulants
May increase prothrombin time (PT) with or without clinical bleeding, requiring careful monitoring.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Treatment is generally symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Small amounts are excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Patients with known hypersensitivity to Cefixime, other cephalosporins, or to any of the excipients.
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
Concurrent use may increase Cefixime Cmax and AUC.
Carbamazepine
Cefixime may increase carbamazepine levels when co-administered.
Warfarin and Anticoagulants
May increase prothrombin time (PT) with or without clinical bleeding, requiring careful monitoring.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Treatment is generally symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Small amounts are excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored under recommended conditions.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in treating various bacterial infections. Ongoing post-marketing surveillance continues to monitor its profile.
Lab Monitoring
- Regular monitoring of renal function may be advised for patients receiving prolonged therapy or those with pre-existing renal impairment. Liver function tests may be monitored if clinically indicated.
Doctor Notes
- Emphasize the importance of completing the full course of treatment to prevent resistance.
- Consider renal function in elderly patients or those with kidney impairment.
- Advise patients about potential drug interactions, especially with anticoagulants.
Patient Guidelines
- Complete the entire prescribed course of treatment, even if symptoms improve.
- Do not share this medication with others.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime may cause dizziness in some patients. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids, especially if experiencing diarrhea. Avoid alcohol consumption during treatment.
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