Xclor
Generic Name
Esomeprazole
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xclor 125 mg suspension | ৳ 190.57 | N/A |
Description
Overview of the medicine
Xclor contains Esomeprazole, a proton pump inhibitor, used to treat conditions caused by excess stomach acid.
Uses & Indications
Dosage
Adults
20-40 mg once daily for 4-8 weeks, depending on indication.
Elderly
No dose adjustment generally required, but caution is advised.
Renal_impairment
No dose adjustment needed for mild to moderate impairment. For severe impairment, caution is advised.
How to Take
Should be taken at least one hour before a meal, swallowed whole with water. Do not chew or crush.
Mechanism of Action
Esomeprazole inhibits the H+/K+-ATPase (proton pump) in gastric parietal cells, thereby suppressing gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted in urine (80%) and feces (20%).
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed after oral administration; bioavailability is about 90% after repeated dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system (CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Monitor INR; may increase bleeding risk.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel.
Methotrexate
May increase methotrexate levels, requiring dose adjustment.
Storage
Store below 30°C, away from moisture and direct sunlight.
Overdose
Symptoms include drowsiness, confusion, blurred vision, tachycardia, nausea, sweating, flushing, headache, dry mouth. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if clearly needed (Category B). Caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Monitor INR; may increase bleeding risk.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel.
Methotrexate
May increase methotrexate levels, requiring dose adjustment.
Storage
Store below 30°C, away from moisture and direct sunlight.
Overdose
Symptoms include drowsiness, confusion, blurred vision, tachycardia, nausea, sweating, flushing, headache, dry mouth. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if clearly needed (Category B). Caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support its efficacy and safety for approved indications.
Lab Monitoring
- Magnesium levels (for long-term use).
- Vitamin B12 levels (for long-term use).
Doctor Notes
- Consider lowest effective dose for shortest duration.
- Re-evaluate need for PPI therapy periodically.
- Not recommended for on-demand use for immediate symptom relief.
Patient Guidelines
- Take as directed by your doctor.
- Report any persistent or worsening symptoms.
- Do not stop taking without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume regular dosing schedule. Do not double dose.
Driving Precautions
May cause dizziness or visual disturbances; avoid driving if affected.
Lifestyle Advice
- Avoid trigger foods (spicy, fatty foods, caffeine).
- Elevate head of bed if you have GERD.
- Maintain a healthy weight.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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