Xenap
Generic Name
Esomeprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xenap 500 mg tablet | ৳ 9.00 | ৳ 63.00 |
Description
Overview of the medicine
Xenap (Esomeprazole) is a proton pump inhibitor that reduces stomach acid production, used to treat conditions like GERD, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Usually 20 mg or 40 mg once daily, depending on condition and severity.
Elderly
No specific dose adjustment needed based on age alone, but monitor for concomitant conditions.
Renal_impairment
No dose adjustment needed for mild to moderate renal impairment. For severe impairment, use with caution.
How to Take
Take whole with water, at least one hour before a meal. Do not chew or crush. For patients with swallowing difficulties, tablets can be dispersed in non-carbonated water.
Mechanism of Action
Esomeprazole inhibits the H+/K+-ATPase (proton pump) in gastric parietal cells, blocking the final step of acid secretion, thereby reducing gastric acidity.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly via urine (about 80%) and feces (about 20%).
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed after oral administration, bioavailability is about 64% (for 20 mg) and 89% (for 40 mg) after single dose.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) system, mainly by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole or any benzimidazole substituted PPIs
- Concomitant use with nelfinavir
Drug Interactions
Diazepam
Decreased clearance of diazepam.
Warfarin
Increased INR/bleeding risk. Monitor INR closely.
Clopidogrel
Reduced antiplatelet effect, avoid concomitant use if possible.
Methotrexate
Increased methotrexate levels. Consider dose reduction or temporary discontinuation of PPI.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach and sight of children.
Overdose
Symptoms are generally mild and include gastrointestinal disturbances like nausea, vomiting, abdominal pain, and diarrhea. Management is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Excretion into breast milk is unknown; a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole or any benzimidazole substituted PPIs
- Concomitant use with nelfinavir
Drug Interactions
Diazepam
Decreased clearance of diazepam.
Warfarin
Increased INR/bleeding risk. Monitor INR closely.
Clopidogrel
Reduced antiplatelet effect, avoid concomitant use if possible.
Methotrexate
Increased methotrexate levels. Consider dose reduction or temporary discontinuation of PPI.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach and sight of children.
Overdose
Symptoms are generally mild and include gastrointestinal disturbances like nausea, vomiting, abdominal pain, and diarrhea. Management is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Excretion into breast milk is unknown; a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired (generic available)
WHO Essential Medicine
YesClinical Trials
Esomeprazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for various acid-related disorders. Studies have shown superior efficacy compared to some other PPIs in certain conditions.
Lab Monitoring
- Magnesium levels (for long-term use, especially with diuretics)
- Chromogranin A (for neuroendocrine tumors, may elevate PPIs)
- Liver function tests (periodically if concern)
Doctor Notes
- Advise patients about potential long-term risks associated with PPI use and monitor for these. Consider lowest effective dose for shortest duration necessary.
- Re-evaluate the need for continued PPI therapy periodically, especially for non-erosive GERD.
- Be aware of drug interactions, especially with clopidogrel and methotrexate.
Patient Guidelines
- Take exactly as prescribed and do not adjust dose without doctor's consultation.
- Report any severe or persistent side effects immediately.
- Do not stop suddenly without consulting doctor, especially if treating GERD or ulcers.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Esomeprazole may cause dizziness or visual disturbances in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the drug affects them.
Lifestyle Advice
- Avoid spicy, fatty, and acidic foods that can trigger symptoms.
- Limit alcohol, caffeine, and smoking.
- Eat smaller, more frequent meals.
- Elevate the head of your bed to reduce nighttime reflux.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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