Xendox
Generic Name
Doxycycline
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xendox 200 mg tablet | ৳ 5.50 | ৳ 55.00 |
Description
Overview of the medicine
Xendox 200 mg Tablet contains Doxycycline, a broad-spectrum tetracycline antibiotic used to treat various bacterial infections, including respiratory tract infections, urinary tract infections, skin infections, and certain sexually transmitted diseases.
Uses & Indications
Dosage
Adults
Standard dose is 200 mg on the first day (as a single dose or 100 mg every 12 hours), followed by 100 mg once daily. For severe infections, 200 mg once daily may be continued.
Elderly
No specific dose adjustment required based on age, but caution advised due to potential comorbidities.
Renal_impairment
No dosage adjustment needed for renal impairment, as doxycycline is primarily excreted in feces.
How to Take
Take with a full glass of water, preferably while sitting or standing, to reduce the risk of esophageal irritation. Can be taken with food to minimize gastric upset.
Mechanism of Action
Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing the attachment of aminoacyl tRNA to the mRNA-ribosome complex. This prevents bacterial growth and replication.
Pharmacokinetics
Onset
Clinical effects typically within 24-48 hours, though plasma levels are achieved much faster.
Excretion
Mainly via feces (biliary route) and urine.
Half life
16-24 hours
Absorption
Well absorbed orally, even in the presence of food and milk, though absorption may be slightly reduced by dairy products and antacids.
Metabolism
Limited hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to tetracyclines or any component of the formulation
- Pregnancy (especially last half) and lactation
- Children under 8 years of age (due to risk of permanent tooth discoloration and bone growth inhibition)
Drug Interactions
Warfarin
May potentiate the effects of anticoagulants; monitor INR.
Penicillins
May interfere with the bactericidal action of penicillins; avoid concurrent use.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; advise additional contraceptive methods.
Antacids, iron preparations, calcium, magnesium, aluminum, bismuth subsalicylate
Reduce absorption of doxycycline; administer at least 2 hours before or 4 hours after.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea. Treatment is supportive; gastric lavage may be considered soon after ingestion. Hemodialysis is not effective.
Pregnancy & Lactation
Contraindicated during pregnancy (especially second and third trimesters due to fetal tooth discoloration and inhibition of bone growth) and lactation (excreted in breast milk and can cause tooth discoloration and bone growth inhibition in nursing infants).
Side Effects
Contraindications
- Hypersensitivity to tetracyclines or any component of the formulation
- Pregnancy (especially last half) and lactation
- Children under 8 years of age (due to risk of permanent tooth discoloration and bone growth inhibition)
Drug Interactions
Warfarin
May potentiate the effects of anticoagulants; monitor INR.
Penicillins
May interfere with the bactericidal action of penicillins; avoid concurrent use.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; advise additional contraceptive methods.
Antacids, iron preparations, calcium, magnesium, aluminum, bismuth subsalicylate
Reduce absorption of doxycycline; administer at least 2 hours before or 4 hours after.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea. Treatment is supportive; gastric lavage may be considered soon after ingestion. Hemodialysis is not effective.
Pregnancy & Lactation
Contraindicated during pregnancy (especially second and third trimesters due to fetal tooth discoloration and inhibition of bone growth) and lactation (excreted in breast milk and can cause tooth discoloration and bone growth inhibition in nursing infants).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (patent expired)
WHO Essential Medicine
YesClinical Trials
Doxycycline has been extensively studied in numerous clinical trials for its efficacy in various bacterial infections, malaria prophylaxis, and dermatological conditions.
Lab Monitoring
- Liver function tests (for long-term therapy or pre-existing hepatic impairment)
- Kidney function tests (if clinically indicated)
- INR (if on anticoagulants)
Doctor Notes
- Advise patients to take with plenty of water to prevent esophageal ulceration.
- Emphasize completion of the full course to prevent antibiotic resistance.
- Counsel on photosensitivity and the need for sun protection.
- Avoid in pregnant women and young children due to teratogenic effects on teeth and bones.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if symptoms improve.
- Avoid lying down for at least 30 minutes after taking the tablet.
- Use sunscreen and protective clothing when outdoors due to photosensitivity.
- Avoid dairy products and antacids around the time of taking Xendox.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it's near the time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances in some individuals; advise caution when driving or operating machinery until effects are known.
Lifestyle Advice
- Maintain good hydration.
- Avoid excessive sun exposure.
- Follow a balanced diet.
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