Xeridon
Generic Name
Paracetamol + Propyphenazone + Caffeine
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xeridon 10 mg tablet | ৳ 4.00 | ৳ 40.00 |
| xeridon 5 mg suspension | ৳ 40.00 | N/A |
Description
Overview of the medicine
Xeridon is a combination painkiller used to relieve various types of pain such as headache, migraine, dental pain, menstrual pain, and musculoskeletal pain, and also to reduce fever. It contains Paracetamol, Propyphenazone (an NSAID), and Caffeine.
Uses & Indications
Dosage
Adults
1-2 tablets, 1-3 times daily. Maximum of 6 tablets in 24 hours.
Elderly
Lower doses might be considered, consult a doctor.
Renal_impairment
Dose adjustment required; avoid if severe impairment. Consult a doctor.
How to Take
For oral use. Take with a glass of water, with or without food. Do not chew or crush the tablet.
Mechanism of Action
Paracetamol acts centrally to produce analgesia and antipyresis. Propyphenazone is a pyrazolone derivative with analgesic, antipyretic, and anti-inflammatory effects, primarily by inhibiting prostaglandin synthesis. Caffeine is a central nervous system stimulant that enhances the analgesic effects of paracetamol and propyphenazone and helps to alleviate fatigue.
Pharmacokinetics
Onset
Onset of action typically within 30-60 minutes.
Excretion
Mainly excreted by the kidneys as metabolites and unchanged drug.
Half life
Paracetamol: 1-4 hours; Propyphenazone: 2-3 hours; Caffeine: 3-7 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract. Peak plasma levels for paracetamol are usually reached within 30-60 minutes, propyphenazone within 1-2 hours, and caffeine within 30-60 minutes.
Metabolism
Primarily metabolized in the liver, mainly by conjugation (paracetamol, propyphenazone) and demethylation/oxidation (caffeine).
Side Effects
Contraindications
- Hypersensitivity to paracetamol, propyphenazone, caffeine or any other pyrazolone derivatives
- Severe hepatic or renal impairment
- Gastric or duodenal ulcers
- G6PD deficiency
- Acute hepatic porphyria
- Pregnancy (especially third trimester) and lactation
Drug Interactions
Alcohol
Increased risk of hepatotoxicity (liver damage) with paracetamol.
Other NSAIDs
Increased risk of gastrointestinal side effects and bleeding.
Cholestyramine
Reduce paracetamol absorption.
Oral contraceptives
May increase caffeine metabolism.
Metoclopramide, Domperidone
Accelerate paracetamol absorption.
Cimetidine, Fluoroquinolones
May reduce caffeine metabolism, leading to increased caffeine levels.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding due to propyphenazone.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep away from direct sunlight.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, liver damage (paracetamol), and CNS stimulation (caffeine). In case of overdose, seek immediate medical attention. Treatment is symptomatic and supportive; N-acetylcysteine is an antidote for paracetamol overdose.
Pregnancy & Lactation
Consult your doctor. Not recommended during the third trimester of pregnancy due to the propyphenazone component (NSAID). Caffeine passes into breast milk and may affect the infant.
Side Effects
Contraindications
- Hypersensitivity to paracetamol, propyphenazone, caffeine or any other pyrazolone derivatives
- Severe hepatic or renal impairment
- Gastric or duodenal ulcers
- G6PD deficiency
- Acute hepatic porphyria
- Pregnancy (especially third trimester) and lactation
Drug Interactions
Alcohol
Increased risk of hepatotoxicity (liver damage) with paracetamol.
Other NSAIDs
Increased risk of gastrointestinal side effects and bleeding.
Cholestyramine
Reduce paracetamol absorption.
Oral contraceptives
May increase caffeine metabolism.
Metoclopramide, Domperidone
Accelerate paracetamol absorption.
Cimetidine, Fluoroquinolones
May reduce caffeine metabolism, leading to increased caffeine levels.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding due to propyphenazone.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep away from direct sunlight.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, liver damage (paracetamol), and CNS stimulation (caffeine). In case of overdose, seek immediate medical attention. Treatment is symptomatic and supportive; N-acetylcysteine is an antidote for paracetamol overdose.
Pregnancy & Lactation
Consult your doctor. Not recommended during the third trimester of pregnancy due to the propyphenazone component (NSAID). Caffeine passes into breast milk and may affect the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Available in pharmacies across Bangladesh
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent expired
Clinical Trials
The active ingredients are well-established, and their combination has been in use for many decades. Specific clinical trials for this exact branded combination may not be widely published, but efficacy and safety are inferred from its components.
Lab Monitoring
- Liver function tests (for prolonged high-dose therapy)
- Renal function tests (for prolonged high-dose therapy)
- Complete blood count (rarely for suspected blood dyscrasias)
Doctor Notes
- Remind patients not to exceed the maximum daily dose of paracetamol from all sources.
- Advise caution in patients with a history of gastrointestinal issues, asthma, or impaired renal/hepatic function.
- Educate patients about potential side effects and drug interactions.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid prolonged use without consulting a doctor.
- Keep out of reach of children.
- Inform your doctor about all other medications you are taking.
- Do not take with other paracetamol-containing products.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness in some individuals. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Stay well hydrated.
- Avoid excessive alcohol consumption.
- Limit additional caffeine intake from coffee, tea, or energy drinks.
- If symptoms persist, consult your doctor.
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Global Brand Names
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