Xerocid
Generic Name
Cefuroxime Axetil
Manufacturer
Healthcare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xerocid 500 mg suspension | ৳ 125.00 | N/A |
Description
Overview of the medicine
Cefuroxime Axetil is a broad-spectrum second-generation cephalosporin antibiotic effective against a wide range of gram-positive and gram-negative bacteria. It is used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
250 mg to 500 mg twice daily, depending on the infection severity. For severe infections, 500 mg twice daily.
Elderly
No specific dose adjustment generally required unless severe renal impairment.
Renal_impairment
Dosage adjustment needed for severe renal impairment (e.g., CrCl < 30 mL/min).
How to Take
Oral administration. Can be taken with food to enhance absorption and reduce gastrointestinal upset. Shake well before use.
Mechanism of Action
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.
Pharmacokinetics
Onset
1 hour
Excretion
Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.
Half life
1-1.5 hours
Absorption
Well absorbed from the gastrointestinal tract, especially when taken with food. Axetil is hydrolyzed to active cefuroxime.
Metabolism
Not extensively metabolized; Axetil is hydrolyzed.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent.
Drug Interactions
Probenecid
May increase cefuroxime levels.
Oral Contraceptives
May reduce efficacy of oral contraceptives (use alternative birth control).
Antacids/H2 blockers/PPIs
May decrease bioavailability of cefuroxime axetil (take 2 hours before or after).
Aminoglycosides/Loop Diuretics
Increased risk of nephrotoxicity.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children. Once constituted, store in a refrigerator and use within 7-10 days.
Overdose
Symptoms may include cerebral irritation leading to convulsions. Management is supportive, hemodialysis may be considered.
Pregnancy & Lactation
Pregnancy: Category B. Generally considered safe, but use only if clearly needed. Lactation: Excreted in breast milk in small amounts. Use with caution.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent.
Drug Interactions
Probenecid
May increase cefuroxime levels.
Oral Contraceptives
May reduce efficacy of oral contraceptives (use alternative birth control).
Antacids/H2 blockers/PPIs
May decrease bioavailability of cefuroxime axetil (take 2 hours before or after).
Aminoglycosides/Loop Diuretics
Increased risk of nephrotoxicity.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children. Once constituted, store in a refrigerator and use within 7-10 days.
Overdose
Symptoms may include cerebral irritation leading to convulsions. Management is supportive, hemodialysis may be considered.
Pregnancy & Lactation
Pregnancy: Category B. Generally considered safe, but use only if clearly needed. Lactation: Excreted in breast milk in small amounts. Use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 years unconstituted, 7-10 days once constituted (refrigerated).
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of cefuroxime axetil for various bacterial infections.
Lab Monitoring
- Renal function (for prolonged therapy or in impaired patients)
- Liver function (rarely)
- Complete Blood Count (CBC)
Doctor Notes
- Ensure patient completes the full course to prevent antibiotic resistance.
- Advise parents on proper measurement and administration for children.
- Counsel on potential GI upset and taking with food.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if symptoms improve.
- Take with food.
- Shake the suspension well before each use.
- Do not share your medication with others.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness, so caution is advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol as it may worsen gastrointestinal side effects.
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