Xerokof
Generic Name
Dextromethorphan Hydrobromide
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xerokof 15 mg syrup | ৳ 40.00 | N/A |
Description
Overview of the medicine
Xerokof is a non-drowsy cough syrup containing Dextromethorphan Hydrobromide, used for the relief of dry and irritating coughs associated with common cold and minor throat irritations. It works by suppressing the cough reflex.
Uses & Indications
Dosage
Adults
10-20 mg (10-20 ml) every 4-6 hours as needed, not to exceed 120 mg (120 ml) in 24 hours.
Elderly
No specific dose adjustment needed, but monitor for adverse effects.
Renal_impairment
Use with caution; dose reduction may be necessary in severe impairment.
How to Take
Oral administration. Measure dose accurately using the provided measuring cup or spoon. May be taken with or without food.
Mechanism of Action
Dextromethorphan acts centrally on the cough center in the medulla oblongata to elevate the cough threshold, thereby suppressing the cough reflex. It does not possess analgesic or addictive properties at therapeutic doses.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Primarily excreted renally as unchanged drug and metabolites.
Half life
2-4 hours
Absorption
Rapidly absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver, primarily via CYP2D6 to dextrorphan (an active metabolite).
Side Effects
Contraindications
- Hypersensitivity to Dextromethorphan or any component
- Concurrent use with MAO inhibitors (within 14 days)
Drug Interactions
SSRIs/TCAs
Increased risk of serotonin syndrome.
MAO Inhibitors
Risk of serotonin syndrome (nausea, vomiting, hyperthermia, muscle rigidity, rapid fluctuations in vital signs).
CYP2D6 Inhibitors (e.g., Fluoxetine, Paroxetine)
May increase dextromethorphan plasma levels, increasing side effects.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, dizziness, drowsiness, blurred vision, nystagmus, ataxia, CNS depression, and respiratory depression. Management is supportive, including gastric lavage or activated charcoal if appropriate, and monitoring vital signs. Naloxone may be used in severe cases.
Pregnancy & Lactation
Use with caution during pregnancy; consult a doctor. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to Dextromethorphan or any component
- Concurrent use with MAO inhibitors (within 14 days)
Drug Interactions
SSRIs/TCAs
Increased risk of serotonin syndrome.
MAO Inhibitors
Risk of serotonin syndrome (nausea, vomiting, hyperthermia, muscle rigidity, rapid fluctuations in vital signs).
CYP2D6 Inhibitors (e.g., Fluoxetine, Paroxetine)
May increase dextromethorphan plasma levels, increasing side effects.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, dizziness, drowsiness, blurred vision, nystagmus, ataxia, CNS depression, and respiratory depression. Management is supportive, including gastric lavage or activated charcoal if appropriate, and monitoring vital signs. Naloxone may be used in severe cases.
Pregnancy & Lactation
Use with caution during pregnancy; consult a doctor. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Studies have shown Dextromethorphan to be effective in suppressing non-productive coughs.
Lab Monitoring
- No specific lab monitoring required for routine use.
- Liver and kidney function tests in prolonged use or with impaired function.
Doctor Notes
- Advise patients against using for chronic cough without diagnosis.
- Educate on the potential for abuse and risks of high doses, especially when combined with other substances.
Patient Guidelines
- Do not exceed recommended dose.
- Avoid driving or operating machinery if drowsiness occurs.
- Consult doctor if cough persists for more than 7 days or is accompanied by fever, rash, or persistent headache.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Avoid irritants like smoke and dust.
- Use a humidifier to moisten the air.
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