Xerosec
Generic Name
Omeprazole 20 mg Capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xerosec 20 mg capsule | ৳ 5.02 | ৳ 50.20 |
Description
Overview of the medicine
Xerosec 20 mg Capsule contains Omeprazole, a proton pump inhibitor used to reduce stomach acid and treat conditions like ulcers and GERD.
Uses & Indications
Dosage
Adults
Duodenal ulcer: 20 mg once daily for 2-4 weeks. Gastric ulcer/GERD: 20 mg once daily for 4-8 weeks. Zollinger-Ellison Syndrome: Initial dose 60 mg once daily.
Elderly
No specific dosage adjustment is usually required, but use with caution in severe hepatic impairment.
Renal_impairment
No dosage adjustment is necessary for patients with impaired renal function.
How to Take
Take one capsule orally, preferably in the morning before food. Swallow the capsule whole with water; do not chew or crush it.
Mechanism of Action
Omeprazole works by irreversibly inhibiting the H+/K+-ATPase enzyme system (proton pump) in the gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Acid inhibitory effect starts within 1 hour, maximal effect within 2 hours.
Excretion
Approximately 80% of metabolites are excreted in the urine and 20% in the feces.
Half life
Plasma elimination half-life is 0.5-1 hour, but duration of acid suppression is much longer.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring within 0.5-3.5 hours. Bioavailability is about 30-40%.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system, mainly CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with Nelfinavir.
Drug Interactions
Warfarin
Omeprazole may prolong the elimination of warfarin, leading to increased INR and bleeding risk. Close monitoring is recommended.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of clopidogrel. Concomitant use should be avoided.
Methotrexate
Concomitant use with methotrexate may increase methotrexate plasma concentrations and prolong its elimination, potentially leading to toxicity.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and transient, including nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Small amounts of omeprazole may pass into breast milk; consult a doctor before use during lactation.
Side Effects
Contraindications
- Hypersensitivity to Omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with Nelfinavir.
Drug Interactions
Warfarin
Omeprazole may prolong the elimination of warfarin, leading to increased INR and bleeding risk. Close monitoring is recommended.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of clopidogrel. Concomitant use should be avoided.
Methotrexate
Concomitant use with methotrexate may increase methotrexate plasma concentrations and prolong its elimination, potentially leading to toxicity.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and transient, including nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Small amounts of omeprazole may pass into breast milk; consult a doctor before use during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated Omeprazole's efficacy and safety in treating various acid-related disorders across diverse patient populations.
Lab Monitoring
- Long-term use (over 3 months) may require monitoring of serum magnesium levels.
- Prolonged therapy (over 1 year) may lead to vitamin B12 deficiency; consider monitoring if clinically indicated.
Doctor Notes
- Assess for potential drug interactions, especially with clopidogrel and warfarin.
- Consider lowest effective dose and shortest duration for GERD treatment.
- Educate patients on potential long-term risks with chronic use.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Swallow the capsule whole; do not chew, crush, or open it.
- Take it preferably in the morning before breakfast.
- Inform your doctor if your symptoms do not improve or worsen.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Omeprazole may cause dizziness or visual disturbances in some patients. If these symptoms occur, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty, acidic foods, caffeine, and chocolate.
- Eat smaller, more frequent meals and avoid lying down immediately after eating.
- Maintain a healthy weight and avoid smoking.
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