Xerosec
Generic Name
Esomeprazole 40 mg
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xerosec 40 mg capsule | ৳ 8.02 | ৳ 80.20 |
Description
Overview of the medicine
Xerosec 40 mg capsule contains Esomeprazole, a proton pump inhibitor that reduces acid production in the stomach, used to treat conditions like GERD, ulcers, and H. pylori infection.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. H. pylori eradication: 40 mg once daily for 10 days (with antibiotics). Zollinger-Ellison Syndrome: 40 mg twice daily, adjusted as needed.
Elderly
No specific dose adjustment required for elderly patients, but caution in those with severe hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take the capsule whole with water at least 30-60 minutes before a meal, preferably in the morning. Do not chew, crush, or break the capsule.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase enzyme system (proton pump) in the gastric parietal cells, thereby blocking the final step of acid secretion.
Pharmacokinetics
Onset
Within 1 hour (acid suppression).
Excretion
Metabolites are primarily excreted in the urine (approximately 80%) and feces (approximately 20%).
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 50-64% (for 40 mg dose), increasing with repeated dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily by CYP2C19 and to a lesser extent by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir (an HIV protease inhibitor).
Drug Interactions
Digoxin
May increase digoxin levels.
Warfarin
May increase INR and prothrombin time, increasing risk of bleeding.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel.
Atazanavir, Nelfinavir
May significantly reduce plasma concentrations, leading to loss of virologic response.
Ketoconazole, Itraconazole
May reduce absorption due to increased gastric pH.
Storage
Store in a cool, dry place below 25°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, confusion, blurred vision, tachycardia, nausea, sweating, and headache. No specific antidote is known. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation as Esomeprazole may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir (an HIV protease inhibitor).
Drug Interactions
Digoxin
May increase digoxin levels.
Warfarin
May increase INR and prothrombin time, increasing risk of bleeding.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel.
Atazanavir, Nelfinavir
May significantly reduce plasma concentrations, leading to loss of virologic response.
Ketoconazole, Itraconazole
May reduce absorption due to increased gastric pH.
Storage
Store in a cool, dry place below 25°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, confusion, blurred vision, tachycardia, nausea, sweating, and headache. No specific antidote is known. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation as Esomeprazole may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the manufacturing date, depending on specific manufacturer guidelines.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Generic versions available
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders. Studies have shown superior efficacy compared to some other PPIs in certain conditions.
Lab Monitoring
- Periodic monitoring of magnesium levels in patients on prolonged therapy (especially with diuretics).
- Vitamin B12 levels in patients on long-term therapy (over 3 years).
Doctor Notes
- Consider lowest effective dose and shortest duration for PPI therapy.
- Monitor for Vitamin B12 and magnesium deficiency in patients on prolonged therapy.
- Exercise caution when co-administering with clopidogrel due to potential reduction in antiplatelet effect.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Swallow the capsule whole; do not chew, crush, or open it.
- Take at least 30-60 minutes before your meal.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or blurred vision in some individuals. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods like spicy foods, fatty foods, chocolate, caffeine, and alcohol.
- Elevate the head of your bed to reduce nighttime reflux.
- Quit smoking as it can worsen GERD symptoms.
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