Adults

The usual adult dose is 200-400 mg daily, given as a single dose or in two divided doses (e.g., 200 mg every 12 hours). For uncomplicated gonorrhea, a single oral dose of 400 mg is recommended.

Elderly

No dose adjustment is typically required based solely on age, but renal function should be assessed, and dosage adjusted accordingly if renal impairment is present.

Renal_impairment

For creatinine clearance 21-60 mL/min, the dose should be reduced to 75% of the standard dose. For creatinine clearance <20 mL/min, the dose should be reduced to 50% of the standard dose.

Onset

Peak plasma concentrations are achieved within 2-6 hours after administration.

Excretion

Approximately 50-60% of the absorbed dose is excreted unchanged in the urine over 24 hours. Some excretion occurs via bile/feces.

Half life

Plasma half-life is typically 3-4 hours, potentially longer in elderly or renally impaired patients.

Absorption

Approximately 40-50% orally absorbed. Absorption is not significantly affected by food.

Metabolism

Cefixime is not extensively metabolized; about 10% of the dose may be converted to an inactive metabolite.

Nifedipine

May increase the absorption and peak serum levels of cefixime.

Probenecid

May increase Cefixime plasma concentrations by decreasing renal excretion.

Carbamazepine

Elevated carbamazepine levels have been reported when co-administered with cefixime.

Oral Anticoagulants (e.g., Warfarin)

May increase prothrombin time (PT) with or without bleeding. Close monitoring of PT/INR is recommended.