Ximocef
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ximocef 20 mg pediatric drop | ৳ 150.00 | N/A |
Description
Overview of the medicine
Ximocef 20 mg Pediatric Drop contains Cefixime, a third-generation cephalosporin antibiotic, used to treat a wide range of bacterial infections in children, including ear, nose, throat, urinary tract, and chest infections.
Uses & Indications
Dosage
Adults
Not applicable for pediatric drops. Consult physician for adult Cefixime dosage (usually 200-400 mg once or twice daily).
Elderly
Not applicable for pediatric drops. Elderly dosage similar to adults but adjust for renal function.
Renal_impairment
For children with creatinine clearance < 20 mL/min, the dose should be reduced by 50%.
How to Take
Administer orally. Shake the bottle well before each use. Use the provided calibrated dropper for accurate measurement of the prescribed dose. Can be taken with or without food.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis, leading to bacterial lysis and death. It shows bactericidal activity against a broad spectrum of Gram-positive and Gram-negative bacteria.
Pharmacokinetics
Onset
Peak plasma concentrations are generally achieved within 2-6 hours post-oral administration.
Excretion
Primarily excreted unchanged via urine (approximately 50% of absorbed dose) and bile.
Half life
The average plasma half-life is 3-4 hours.
Absorption
Approximately 40-50% absorbed orally. Food does not significantly affect absorption.
Metabolism
Cefixime is not extensively metabolized in the body. Some active metabolites may be formed.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Warfarin
Concurrent use may increase prothrombin time and INR. Close monitoring and dosage adjustment of anticoagulants may be necessary.
Probenecid
Increases Cefixime plasma concentrations by decreasing its renal clearance.
Carbamazepine
Increased plasma levels of Carbamazepine have been reported when co-administered with Cefixime.
Oral Contraceptives
May rarely reduce the efficacy of oral contraceptives; advise patients to use an additional contraceptive method.
Storage
Store in a cool, dry place below 30°C. Protect from light. Keep out of reach of children. Do not freeze.
Overdose
In case of overdose, symptoms may include gastrointestinal disturbances (nausea, vomiting, diarrhea) and possibly seizures. Treatment is supportive and symptomatic. Hemodialysis or peritoneal dialysis may be helpful in removing the drug from the blood.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, Cefixime should be used during pregnancy only if clearly needed. Cefixime is excreted in breast milk in small amounts; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Warfarin
Concurrent use may increase prothrombin time and INR. Close monitoring and dosage adjustment of anticoagulants may be necessary.
Probenecid
Increases Cefixime plasma concentrations by decreasing its renal clearance.
Carbamazepine
Increased plasma levels of Carbamazepine have been reported when co-administered with Cefixime.
Oral Contraceptives
May rarely reduce the efficacy of oral contraceptives; advise patients to use an additional contraceptive method.
Storage
Store in a cool, dry place below 30°C. Protect from light. Keep out of reach of children. Do not freeze.
Overdose
In case of overdose, symptoms may include gastrointestinal disturbances (nausea, vomiting, diarrhea) and possibly seizures. Treatment is supportive and symptomatic. Hemodialysis or peritoneal dialysis may be helpful in removing the drug from the blood.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, Cefixime should be used during pregnancy only if clearly needed. Cefixime is excreted in breast milk in small amounts; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety profile of Cefixime in treating various bacterial infections, including those in pediatric populations.
Lab Monitoring
- Periodic monitoring of renal and hepatic function, and complete blood count (CBC) may be advised during prolonged therapy.
- Monitor INR for patients on warfarin concurrently.
Doctor Notes
- Emphasize the importance of completing the full course of therapy to parents/caregivers, even if the child's symptoms improve.
- Counsel about potential allergic reactions, especially in children with a history of penicillin allergy, and advise immediate medical attention for severe reactions.
- Provide clear instructions on accurate dose measurement using the provided dropper.
Patient Guidelines
- Complete the full prescribed course of treatment, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
- Do not stop taking this medicine without consulting your doctor.
- Use the provided dropper for accurate measurement. Do not use household spoons.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If a dose is missed, administer it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, if dizziness or other adverse effects occur, caution should be advised.
Lifestyle Advice
- Encourage good hygiene practices to prevent future infections. Ensure adequate hydration during treatment.
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