Ximocef
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ximocef 200 mg capsule | ৳ 40.00 | ৳ 160.00 |
Description
Overview of the medicine
Ximocef 200 mg Capsule contains Cefixime, a third-generation cephalosporin antibiotic. It is effective against a wide range of bacterial infections including those of the respiratory tract, urinary tract, ear, nose, throat, and uncomplicated gonorrhea.
Uses & Indications
Dosage
Adults
200-400 mg once daily or 200 mg every 12 hours, depending on the severity of infection. Duration usually 7-14 days.
Elderly
No dosage adjustment needed unless severe renal impairment.
Renal_impairment
Dose adjustment required for creatinine clearance <60 mL/min. For CrCl 21-60 mL/min, 200 mg daily; for CrCl <20 mL/min, 100 mg daily.
How to Take
Ximocef 200 mg Capsule should be taken orally, with or without food. For best absorption and to minimize gastrointestinal upset, it is often recommended to take it with food.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan units, ultimately leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Typically within 1 hour.
Excretion
Mainly via renal excretion (approximately 50% unchanged in urine) and biliary excretion.
Half life
Approximately 3-4 hours.
Absorption
Approximately 30-50% orally absorbed. Food slightly delays absorption but does not significantly affect the extent.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of severe hypersensitivity reaction to penicillin (due to potential cross-reactivity)
Drug Interactions
Carbamazepine
Cefixime may increase carbamazepine levels.
Oral contraceptives
May reduce efficacy of oral contraceptives (though controversial, advisable to use additional contraception).
Warfarin and other anticoagulants
May increase prothrombin time (INR), requiring close monitoring and dose adjustment of anticoagulants.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Small amounts are excreted in breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of severe hypersensitivity reaction to penicillin (due to potential cross-reactivity)
Drug Interactions
Carbamazepine
Cefixime may increase carbamazepine levels.
Oral contraceptives
May reduce efficacy of oral contraceptives (though controversial, advisable to use additional contraception).
Warfarin and other anticoagulants
May increase prothrombin time (INR), requiring close monitoring and dose adjustment of anticoagulants.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Small amounts are excreted in breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA (Bangladesh)
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Cefixime has been extensively studied in various clinical trials demonstrating its efficacy and safety across a broad spectrum of bacterial infections. Ongoing research may explore new indications or formulations.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with pre-existing renal impairment
- Complete blood count (CBC) during prolonged therapy
- Liver function tests (LFTs) if liver dysfunction suspected
Doctor Notes
- Advise patients to complete the full course of therapy.
- Caution in patients with a history of penicillin allergy.
- Monitor renal function in elderly and renally impaired patients.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not skip doses or stop taking the medicine early, even if you feel better.
- Inform your doctor about any severe diarrhea or allergic reactions.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime may cause dizziness in some patients. Patients should be advised to exercise caution when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
- Avoid alcohol consumption during antibiotic treatment.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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