Xitabin
Generic Name
Xitabine
Manufacturer
Medilife Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xitabin 500 mg tablet | ৳ 125.00 | ৳ 750.00 |
Description
Overview of the medicine
Xitabin 500 mg Tablet is a broad-spectrum antibiotic belonging to the fluoroquinolone class. It is effective against a wide range of bacterial infections in various parts of the body.
Uses & Indications
Dosage
Adults
Typically 500 mg once daily or 250 mg twice daily, depending on the severity and type of infection. Duration usually 7-14 days.
Elderly
No specific dose adjustment is generally required unless there is significant renal impairment. Monitor renal function.
Renal_impairment
Dosage reduction may be necessary for patients with creatinine clearance < 50 mL/min. Consult physician for specific guidelines.
How to Take
Take the tablet whole with water, with or without food. Do not crush or chew. It is advisable to take at the same time each day.
Mechanism of Action
Xitabine inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.
Pharmacokinetics
Onset
Bactericidal effects typically begin within 1-2 hours of administration.
Excretion
Mainly excreted by the kidneys, with a significant portion appearing unchanged in urine.
Half life
Approximately 6-8 hours, allowing for once or twice daily dosing.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver, forming inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Xitabine or other fluoroquinolones.
- History of tendon disorders related to fluoroquinolone administration.
- Children and adolescents below 18 years of age (due to potential for cartilage damage).
Drug Interactions
Warfarin
Enhanced anticoagulant effect, leading to increased bleeding risk. Monitor INR closely.
Theophylline
Increased plasma levels of theophylline, potentially leading to toxicity. Monitor theophylline levels.
Antacids, iron, zinc, sucralfate
Reduced absorption of Xitabine. Administer Xitabine at least 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be considered. Monitor vital signs and ECG.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to potential risks to the fetus/infant. Consult a doctor to weigh benefits against risks.
Side Effects
Contraindications
- Hypersensitivity to Xitabine or other fluoroquinolones.
- History of tendon disorders related to fluoroquinolone administration.
- Children and adolescents below 18 years of age (due to potential for cartilage damage).
Drug Interactions
Warfarin
Enhanced anticoagulant effect, leading to increased bleeding risk. Monitor INR closely.
Theophylline
Increased plasma levels of theophylline, potentially leading to toxicity. Monitor theophylline levels.
Antacids, iron, zinc, sucralfate
Reduced absorption of Xitabine. Administer Xitabine at least 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be considered. Monitor vital signs and ECG.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to potential risks to the fetus/infant. Consult a doctor to weigh benefits against risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent protected
Clinical Trials
Extensive Phase III clinical trials demonstrated efficacy and safety in various bacterial infections. Post-marketing surveillance continues to monitor long-term safety.
Lab Monitoring
- Renal function tests (creatinine clearance) if prolonged therapy or pre-existing impairment.
- Liver function tests (ALT, AST) periodically.
- Complete blood count (CBC) if clinically indicated.
Doctor Notes
- Emphasize patient adherence to the full course to minimize resistance development.
- Counsel patients on potential severe side effects (tendon issues, neuropathy) and to seek immediate medical attention if they occur.
- Consider drug-drug interactions, especially with antacids and anticoagulants.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Do not share your medicine with others.
- Report any unusual side effects, especially tendon pain, numbness, or tingling, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose.
Driving Precautions
Xitabin may cause dizziness or visual disturbances. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Stay well-hydrated by drinking plenty of fluids.
- Avoid excessive exposure to sunlight or artificial UV light, as Xitabine can cause photosensitivity.
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Global Brand Names
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