Xoferon
Generic Name
Iron Polymaltose Complex
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xoferon 100 mg injection | ৳ 325.98 | N/A |
Description
Overview of the medicine
Xoferon contains Iron Polymaltose Complex, a non-ionic iron preparation used for the treatment and prevention of iron deficiency anemia.
Uses & Indications
Dosage
Adults
Typically 1-2 capsules daily, or as directed by physician.
Elderly
Similar to adult dosage, careful monitoring is advised.
Renal_impairment
No specific dose adjustment is usually required, but caution is advised in severe cases.
How to Take
Administer orally, preferably during or after meals to minimize gastrointestinal upset.
Mechanism of Action
Iron Polymaltose Complex is absorbed via an active mechanism, delivering iron to the transferrin and ferritin protein stores without causing a 'free iron' burden, thus reducing gastrointestinal side effects. It is primarily used for hemoglobin synthesis.
Pharmacokinetics
Onset
Gradual, improvement in hemoglobin levels usually observed within 2-3 weeks.
Excretion
Minimal, primarily via bile, urine, sweat, and shedding of cells from the intestinal mucosa.
Half life
Iron half-life in the body is complex and highly variable, as it's recycled and stored; not typically described by a single pharmacokinetic half-life.
Absorption
Controlled and dose-dependent absorption in the small intestine, with higher bioavailability compared to ferrous salts.
Metabolism
Absorbed iron is transported by transferrin to the bone marrow for hemoglobin synthesis and stored as ferritin in the liver and reticuloendothelial system.
Side Effects
Contraindications
- Iron overload (e.g., hemochromatosis, hemosiderosis)
- Anemias not caused by iron deficiency (e.g., megaloblastic anemia, hemolytic anemia)
Drug Interactions
Antacids
Reduced iron absorption. Separate administration by at least 2 hours.
Tetracyclines
Reduced absorption of both iron and tetracyclines. Separate administration by several hours.
Thyroid hormones
Reduced absorption of thyroid hormones. Separate administration by several hours.
Storage
Store below 30°C, in a dry place, away from light and moisture.
Overdose
Symptoms include gastric irritation, abdominal pain, vomiting, diarrhea. Severe overdose can lead to metabolic acidosis, shock, and organ damage. Management involves gastric lavage, supportive care, and chelation therapy if indicated.
Pregnancy & Lactation
Considered safe and often prescribed during pregnancy and lactation for preventing and treating iron deficiency.
Side Effects
Contraindications
- Iron overload (e.g., hemochromatosis, hemosiderosis)
- Anemias not caused by iron deficiency (e.g., megaloblastic anemia, hemolytic anemia)
Drug Interactions
Antacids
Reduced iron absorption. Separate administration by at least 2 hours.
Tetracyclines
Reduced absorption of both iron and tetracyclines. Separate administration by several hours.
Thyroid hormones
Reduced absorption of thyroid hormones. Separate administration by several hours.
Storage
Store below 30°C, in a dry place, away from light and moisture.
Overdose
Symptoms include gastric irritation, abdominal pain, vomiting, diarrhea. Severe overdose can lead to metabolic acidosis, shock, and organ damage. Management involves gastric lavage, supportive care, and chelation therapy if indicated.
Pregnancy & Lactation
Considered safe and often prescribed during pregnancy and lactation for preventing and treating iron deficiency.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in all pharmacies
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials support the efficacy and safety of Iron Polymaltose Complex in treating iron deficiency anemia with fewer gastrointestinal side effects compared to ferrous salts.
Lab Monitoring
- Hemoglobin and hematocrit levels
- Serum ferritin levels
- Transferrin saturation
Doctor Notes
- Emphasize proper diagnosis of iron deficiency before starting therapy.
- Advise patients about common, harmless side effects like dark stools.
- Counsel on concomitant medication interactions.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the recommended dose.
- Store in a cool, dry place.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Xoferon is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in iron (e.g., red meat, leafy greens, fortified cereals).
- Consume Vitamin C-rich foods (e.g., oranges, tomatoes) to enhance iron absorption.
- Avoid taking iron supplements with tea, coffee, or milk as they can inhibit absorption.
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