Xynor
Generic Name
Norethisterone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xynor 500 mg tablet | ৳ 6.50 | ৳ 65.00 |
Description
Overview of the medicine
Xynor contains Norethisterone, a synthetic progestogen. It is primarily used to treat various menstrual disorders such as heavy periods, painful periods, irregular periods, and premenstrual tension. It can also be used in the management of endometriosis and certain breast conditions, and sometimes as a component in hormone replacement therapy or contraception.
Uses & Indications
Dosage
Adults
For DUB: 5 mg three times daily for 10 days. For Menorrhagia/Endometriosis: 5-15 mg daily for 5-10 days per cycle, or continuously for endometriosis. For postponement of menstruation: 5 mg three times daily, starting 3 days before expected period.
Elderly
Use with caution. Dosage adjustment may be required in case of impaired hepatic or renal function.
Renal_impairment
Use with caution. Dosage adjustment may be necessary.
How to Take
Oral administration, taken with or without food.
Mechanism of Action
Norethisterone acts as a synthetic progestogen, mimicking the effects of natural progesterone. It primarily affects the endometrium, causing it to change from a proliferative to a secretory phase. When used for contraception, it inhibits ovulation by suppressing the release of gonadotropins (LH and FSH) from the pituitary gland. It also increases the viscosity of cervical mucus, making it difficult for sperm to penetrate, and alters the endometrium to prevent implantation.
Pharmacokinetics
Onset
Effects on endometrium seen within hours to days; ovulation inhibition requires sustained use.
Excretion
Excreted primarily in urine (50-70%) and feces (20-40%) as metabolites.
Half life
Elimination half-life ranges from 5 to 10 hours.
Absorption
Rapidly and extensively absorbed after oral administration. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily via reduction and conjugation.
Side Effects
Contraindications
- Pregnancy (known or suspected)
- Undiagnosed vaginal bleeding
- History of breast cancer or other progestogen-sensitive cancers
- Severe liver disease or tumors
- Active venous thromboembolism or history of idiopathic venous thromboembolism
- Hypersensitivity to norethisterone or any component of the formulation
Drug Interactions
Grapefruit Juice
May increase norethisterone levels.
Ritonavir, Nelfinavir
May reduce efficacy.
Warfarin/Anticoagulants
May alter anticoagulant effect.
Enzyme Inducers (e.g., Carbamazepine, Rifampicin, Phenytoin)
May reduce efficacy of norethisterone.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, and vaginal bleeding. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Contraindicated during pregnancy. Norethisterone passes into breast milk; therefore, its use during lactation should be carefully considered, and only if the potential benefits outweigh the risks to the infant.
Side Effects
Contraindications
- Pregnancy (known or suspected)
- Undiagnosed vaginal bleeding
- History of breast cancer or other progestogen-sensitive cancers
- Severe liver disease or tumors
- Active venous thromboembolism or history of idiopathic venous thromboembolism
- Hypersensitivity to norethisterone or any component of the formulation
Drug Interactions
Grapefruit Juice
May increase norethisterone levels.
Ritonavir, Nelfinavir
May reduce efficacy.
Warfarin/Anticoagulants
May alter anticoagulant effect.
Enzyme Inducers (e.g., Carbamazepine, Rifampicin, Phenytoin)
May reduce efficacy of norethisterone.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, and vaginal bleeding. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Contraindicated during pregnancy. Norethisterone passes into breast milk; therefore, its use during lactation should be carefully considered, and only if the potential benefits outweigh the risks to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years (refer to package for exact date)
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Generic (patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Norethisterone for its approved indications.
Lab Monitoring
- Regular blood pressure monitoring
- Liver function tests
- Lipid profile
Doctor Notes
- Assess patient's medical history for thromboembolic risks, liver disease, and breast cancer before prescribing.
- Advise patients on appropriate use for specific indications (e.g., contraception vs. menstrual disorder treatment).
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Report any unusual or severe side effects immediately.
- Do not stop taking the medicine abruptly without consulting your doctor.
- If using for contraception, ensure understanding of proper usage.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Norethisterone may cause dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain a healthy lifestyle, including a balanced diet and regular exercise.
- Avoid smoking, especially if you have other cardiovascular risk factors.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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