Zacort
Generic Name
Deflazacort
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zacort 6 mg suspension | ৳ 200.00 | N/A |
Description
Overview of the medicine
Zacort 6 mg Suspension contains Deflazacort, a corticosteroid used for its anti-inflammatory and immunosuppressive effects. It is used to treat various conditions including allergic disorders, rheumatic diseases, and certain autoimmune conditions.
Uses & Indications
Dosage
Adults
Initial dose typically 6-90 mg daily, depending on the condition and severity. Maintenance dose should be individualized and gradually reduced to the lowest effective dose.
Elderly
No specific dose adjustment required, but use with caution due to increased risk of side effects.
Renal_impairment
No specific dose adjustment usually required, but monitoring is advised in severe cases.
How to Take
Take orally, preferably with or after food to minimize gastrointestinal upset. Shake the suspension well before use. Use a calibrated measuring device for accurate dosing.
Mechanism of Action
Deflazacort acts as a glucocorticoid, binding to intracellular glucocorticoid receptors. This complex then translocates to the nucleus, where it modulates gene expression, leading to anti-inflammatory and immunosuppressive effects by inhibiting the release of inflammatory mediators and altering immune cell function.
Pharmacokinetics
Onset
Within hours for anti-inflammatory effects.
Excretion
Mainly excreted via the kidneys (approximately 70%) and feces (approximately 30%).
Half life
Active metabolite has a half-life of 1.1-2.0 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract and converted to its active metabolite, deflazacort 21-oic acid.
Metabolism
Extensively metabolized in the liver to the active metabolite, deflazacort 21-oic acid.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines during high-dose corticosteroid therapy.
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding/ulceration.
Antidiabetics
May increase blood glucose levels, requiring adjustment of antidiabetic medication.
Live/Attenuated Vaccines
Increased risk of severe infection; avoid during immunosuppressive doses.
Anticoagulants (e.g., Warfarin)
May alter anticoagulant effects; monitor INR.
Diuretics (e.g., Thiazides, Loop diuretics)
Increased risk of hypokalemia.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase deflazacort levels and risk of side effects.
CYP3A4 Inducers (e.g., Rifampicin, Phenytoin, Carbamazepine)
May reduce deflazacort levels and efficacy.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with corticosteroids is rare. Symptoms may include exaggeration of known side effects. Management is supportive and symptomatic; gradual withdrawal is usually necessary after prolonged high-dose therapy.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Corticosteroids are excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines during high-dose corticosteroid therapy.
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding/ulceration.
Antidiabetics
May increase blood glucose levels, requiring adjustment of antidiabetic medication.
Live/Attenuated Vaccines
Increased risk of severe infection; avoid during immunosuppressive doses.
Anticoagulants (e.g., Warfarin)
May alter anticoagulant effects; monitor INR.
Diuretics (e.g., Thiazides, Loop diuretics)
Increased risk of hypokalemia.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase deflazacort levels and risk of side effects.
CYP3A4 Inducers (e.g., Rifampicin, Phenytoin, Carbamazepine)
May reduce deflazacort levels and efficacy.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with corticosteroids is rare. Symptoms may include exaggeration of known side effects. Management is supportive and symptomatic; gradual withdrawal is usually necessary after prolonged high-dose therapy.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Corticosteroids are excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when unopened. Refer to the specific product packaging for exact shelf life.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available, original patent expired
Clinical Trials
Deflazacort has been extensively studied in clinical trials for various inflammatory and autoimmune conditions, demonstrating efficacy and a generally favorable side effect profile compared to some other corticosteroids.
Lab Monitoring
- Blood glucose levels
- Blood pressure
- Electrolytes (especially potassium)
- Bone mineral density (with long-term use)
- Ophthalmological exams (for glaucoma/cataracts)
- Growth in pediatric patients.
Doctor Notes
- Emphasize the importance of gradual tapering to prevent adrenal crisis.
- Advise patients on calcium and vitamin D supplementation for bone health with prolonged use.
- Counsel patients on potential mood changes and to report any severe psychological effects.
- Monitor for signs of infection and advise prompt reporting.
Patient Guidelines
- Do not stop this medicine suddenly, especially after prolonged use, as it can cause withdrawal symptoms. Your doctor will gradually reduce your dose.
- Take with food to minimize stomach upset.
- Inform your doctor about all other medications you are taking.
- Report any signs of infection (e.g., fever, sore throat) immediately.
- Avoid contact with people who have infections like chickenpox or measles.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double a dose to make up for a missed one.
Driving Precautions
Deflazacort may cause dizziness or visual disturbances in some patients. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health.
- Engage in regular, moderate exercise if possible.
- Avoid excessive alcohol consumption.
- Monitor blood sugar levels if you have diabetes or are at risk.
- Report any unusual mood changes or psychological disturbances.
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