Zacort
Generic Name
Deflazacort
Manufacturer
Reneta Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zacort 6 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Zacort 6 mg tablet contains Deflazacort, a corticosteroid used to treat a wide range of inflammatory and autoimmune conditions. It works by reducing inflammation and suppressing the immune system.
Uses & Indications
Dosage
Adults
Typically 6-90 mg daily, adjusted according to the condition and patient response. For DMD, initial dosage 0.9 mg/kg/day.
Elderly
Caution advised, lower doses may be required due to increased sensitivity and potential comorbidities.
Renal_impairment
No specific dose adjustment generally needed, but monitor carefully.
How to Take
Oral administration. Can be taken with or without food. It is recommended to take it in the morning.
Mechanism of Action
Deflazacort is a glucocorticoid that binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene expression. This leads to anti-inflammatory and immunosuppressive effects by inhibiting the release of inflammatory mediators and altering immune cell function.
Pharmacokinetics
Onset
Variable, typically within hours to days depending on condition.
Excretion
Mainly excreted via urine (approximately 70%) and feces (approximately 30%) as metabolites.
Half life
The active metabolite has a plasma half-life of approximately 1.5-2 hours.
Absorption
Readily absorbed from the gastrointestinal tract, rapidly converted to its active metabolite, 21-desacetyl deflazacort.
Metabolism
Primarily metabolized in the liver to its active metabolite, 21-desacetyl deflazacort, by esterases. Further metabolized by hydroxylation.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to deflazacort or any excipients
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration.
Anticoagulants
May alter anticoagulant effects, requiring dose adjustment.
Ketoconazole, Erythromycin
May increase plasma concentrations of deflazacort.
Insulin, oral hypoglycemic agents
May reduce hypoglycemic effects, requiring dose adjustment.
Rifampicin, Phenytoin, Phenobarbital
May reduce the efficacy of deflazacort.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include exaggerated side effects. Management is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Small amounts are excreted in breast milk; advise caution or consider alternative feeding methods.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to deflazacort or any excipients
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration.
Anticoagulants
May alter anticoagulant effects, requiring dose adjustment.
Ketoconazole, Erythromycin
May increase plasma concentrations of deflazacort.
Insulin, oral hypoglycemic agents
May reduce hypoglycemic effects, requiring dose adjustment.
Rifampicin, Phenytoin, Phenobarbital
May reduce the efficacy of deflazacort.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include exaggerated side effects. Management is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Small amounts are excreted in breast milk; advise caution or consider alternative feeding methods.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA)
Patent Status
Generic available
Clinical Trials
Deflazacort has undergone various clinical trials, particularly for Duchenne Muscular Dystrophy, demonstrating efficacy in improving muscle strength and delaying disease progression.
Lab Monitoring
- Blood glucose levels
- Blood pressure
- Bone mineral density (long-term use)
- Electrolyte levels
- Growth in children (long-term use)
Doctor Notes
- Educate patients on the importance of gradual tapering off the drug.
- Monitor for signs of adrenal insufficiency during and after treatment.
- Advise patients about potential bone health issues and necessary supplements.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor.
- Take exactly as prescribed.
- Report any unusual side effects to your doctor.
- Avoid close contact with people who have infections.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Deflazacort is generally not expected to impair the ability to drive or operate machinery. However, if side effects like dizziness or vision changes occur, avoid these activities.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D.
- Regular exercise, if appropriate, can help maintain bone health.
- Avoid excessive alcohol consumption.
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