Zedex
Generic Name
Dextromethorphan HBr + Phenylephrine HCl + Chlorpheniramine Maleate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zedex 20 mg tablet | ৳ 1.50 | ৳ 45.00 |
Description
Overview of the medicine
Zedex syrup is a combination medication used to relieve symptoms of common cold, flu, allergies, and other respiratory illnesses. It helps to suppress cough, reduce nasal congestion, and alleviate sneezing and watery eyes.
Uses & Indications
Dosage
Adults
10 ml (2 teaspoonfuls) 3-4 times a day, or as directed by the physician.
Elderly
Use with caution. Dosage adjustment may be required.
Renal_impairment
Use with caution. Dosage adjustment may be required.
How to Take
Orally. Administer with or without food. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Dextromethorphan acts on the cough center in the medulla to elevate the cough threshold. Phenylephrine is a sympathomimetic amine that acts as a decongestant by vasoconstricting blood vessels in the nasal passages. Chlorpheniramine Maleate is a first-generation antihistamine that blocks H1 histamine receptors, reducing allergic symptoms like sneezing and runny nose.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Mainly renal, some fecal.
Half life
Dextromethorphan: 2-4 hours (extensive metabolizers), up to 24 hours (poor metabolizers); Phenylephrine: 2-3 hours; Chlorpheniramine: 12-43 hours.
Absorption
Well absorbed orally. Dextromethorphan undergoes rapid and extensive first-pass metabolism. Phenylephrine has variable oral bioavailability. Chlorpheniramine is readily absorbed.
Metabolism
Dextromethorphan: Hepatic (CYP2D6); Phenylephrine: Liver and gut wall (MAO); Chlorpheniramine: Hepatic.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation
- Patients currently taking or within 14 days of stopping Monoamine Oxidase Inhibitors (MAOIs)
- Severe hypertension or coronary artery disease (due to phenylephrine)
- Closed-angle glaucoma, prostatic hypertrophy (due to chlorpheniramine)
Drug Interactions
MAOIs
Concomitant use with MAOIs can lead to hypertensive crisis and severe adverse reactions.
Antihypertensive drugs
Phenylephrine may reduce the effect of antihypertensive drugs.
CNS depressants (alcohol, sedatives)
Increased sedation due to chlorpheniramine.
Storage
Store in a cool, dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, dizziness, nausea, vomiting, agitation, hallucinations, tachycardia, hypertension, and convulsions. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered in recent overdose.
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation
- Patients currently taking or within 14 days of stopping Monoamine Oxidase Inhibitors (MAOIs)
- Severe hypertension or coronary artery disease (due to phenylephrine)
- Closed-angle glaucoma, prostatic hypertrophy (due to chlorpheniramine)
Drug Interactions
MAOIs
Concomitant use with MAOIs can lead to hypertensive crisis and severe adverse reactions.
Antihypertensive drugs
Phenylephrine may reduce the effect of antihypertensive drugs.
CNS depressants (alcohol, sedatives)
Increased sedation due to chlorpheniramine.
Storage
Store in a cool, dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, dizziness, nausea, vomiting, agitation, hallucinations, tachycardia, hypertension, and convulsions. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered in recent overdose.
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, drugstores
Approval Status
Approved by DGDA
Patent Status
Generic
Clinical Trials
Not typically available for common OTC combination cough/cold remedies; efficacy is based on established individual components.
Lab Monitoring
- No specific lab monitoring required for routine use.
Doctor Notes
- Advise patients about potential drowsiness and to avoid activities requiring mental alertness.
- Caution in patients with chronic respiratory conditions, cardiovascular diseases, or diabetes.
- Patients with hepatic or renal impairment should use with caution.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid driving or operating heavy machinery if drowsiness occurs.
- Do not use with other cough and cold medicines containing similar ingredients.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause drowsiness. Avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Ensure adequate rest and hydration.
- Avoid irritants like smoke and dust.
- Gargle with warm salt water for throat irritation.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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