Zemicef Max
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zemicef max 100 mg pediatric drop | ৳ 250.00 | N/A |
Description
Overview of the medicine
Zemicef Max (Cefixime) is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections including those of the respiratory tract, urinary tract, and otitis media. It works by inhibiting bacterial cell wall synthesis.
Uses & Indications
Dosage
Adults
Adults: 400 mg once daily or 200 mg twice daily. The duration of treatment depends on the infection.
Elderly
No specific dose adjustment is required for elderly patients unless they have severe renal impairment.
Renal_impairment
For patients with creatinine clearance < 60 mL/min, dosage adjustment is necessary. Consult product leaflet for specific guidelines.
How to Take
Zemicef Max can be taken with or without food. For best absorption and to minimize gastrointestinal upset, it may be taken with food.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to the lysis and death of bacterial cells.
Pharmacokinetics
Onset
Onset of action is relatively rapid.
Excretion
Primarily renal, with approximately 50% of an absorbed dose excreted unchanged in urine within 24 hours. Some biliary excretion also occurs.
Half life
Plasma half-life is typically 3-4 hours, potentially longer in elderly or renally impaired patients.
Absorption
Approximately 40-50% orally absorbed. Absorption is not significantly altered by food.
Metabolism
Limited hepatic metabolism; a significant portion is excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reaction to penicillin.
Drug Interactions
Warfarin
May increase prothrombin time; monitor INR closely.
Probenecid
Increases cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
May increase carbamazepine levels; monitor for toxicity.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Treatment should be symptomatic and supportive. Hemodialysis or peritoneal dialysis does not remove Cefixime in significant quantities.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use with caution during pregnancy and lactation; consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reaction to penicillin.
Drug Interactions
Warfarin
May increase prothrombin time; monitor INR closely.
Probenecid
Increases cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
May increase carbamazepine levels; monitor for toxicity.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Treatment should be symptomatic and supportive. Hemodialysis or peritoneal dialysis does not remove Cefixime in significant quantities.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use with caution during pregnancy and lactation; consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Available in pharmacies and hospitals in Bangladesh
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has been extensively studied in numerous clinical trials demonstrating its efficacy and safety across various bacterial infections in both adult and pediatric populations. Data is available in published medical literature.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, creatinine clearance) for patients with severe renal impairment or during prolonged therapy. Liver function tests may be considered in some cases.
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent bacterial resistance and recurrence of infection.
- Advise patients to seek medical attention if severe diarrhea develops during or after treatment.
- Consider renal dose adjustment in elderly patients or those with pre-existing renal impairment.
Patient Guidelines
- Always complete the full prescribed course of antibiotics, even if symptoms improve, to prevent the development of antibiotic resistance.
- Do not share this medicine with others, even if they have similar symptoms.
- Inform your doctor immediately if you experience severe or persistent diarrhea, as it could be a sign of *Clostridium difficile*-associated diarrhea.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Generally considered safe for driving or operating machinery. However, if side effects such as dizziness or lightheadedness occur, avoid these activities.
Lifestyle Advice
- Maintain good hydration, especially if experiencing diarrhea.
- Avoid consuming alcohol during the course of treatment, although direct interactions are not well-established.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.