Zero
Generic Name
Nimesulide 12 mg Powder
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zero 12 mg powder | ৳ 3.00 | N/A |
Description
Overview of the medicine
Zero 12 mg Powder is a non-steroidal anti-inflammatory drug (NSAID) used for the short-term treatment of acute pain and fever in children. It works by reducing pain and inflammation.
Uses & Indications
Dosage
Adults
Not for adult use in this formulation (12 mg). Adults typically use higher doses (e.g., 100 mg tablets).
Elderly
Not for elderly use in this formulation (12 mg). Elderly patients require careful monitoring due to increased risk of side effects.
Renal_impairment
Use with caution in mild to moderate renal impairment; dose reduction may be necessary. Contraindicated in severe renal impairment.
How to Take
Empty the contents of the sachet into a glass of water, stir well until the powder is fully dissolved, and drink immediately. Administer after meals to reduce gastrointestinal upset.
Mechanism of Action
Nimesulide acts primarily as a selective inhibitor of cyclooxygenase-2 (COX-2) enzyme. This leads to the inhibition of prostaglandin synthesis, which are mediators of inflammation, pain, and fever.
Pharmacokinetics
Onset
Within 30-60 minutes for analgesic and antipyretic effects.
Excretion
Mainly excreted in the urine (around 50-60%) and feces (around 20-30%) as metabolites.
Half life
Approximately 2 to 5 hours.
Absorption
Rapidly and well absorbed after oral administration. Peak plasma concentrations are reached within 1.5 to 3 hours.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 2C9 (CYP2C9), to 4-hydroxynimesulide, which also possesses pharmacological activity.
Side Effects
Contraindications
- History of gastrointestinal bleeding or ulceration
- Severe hepatic impairment
- Severe renal impairment
- Severe heart failure
- Known hypersensitivity to nimesulide or other NSAIDs
- Children under 6 months of age
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma methotrexate levels and toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics and Antihypertensives
Reduced efficacy of diuretics and antihypertensive agents.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, epigastric pain, nausea, vomiting, and gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Contraindicated during pregnancy, especially in the third trimester due to potential fetal harm (e.g., premature closure of the ductus arteriosus). Not recommended during lactation as nimesulide may be excreted in breast milk.
Side Effects
Contraindications
- History of gastrointestinal bleeding or ulceration
- Severe hepatic impairment
- Severe renal impairment
- Severe heart failure
- Known hypersensitivity to nimesulide or other NSAIDs
- Children under 6 months of age
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma methotrexate levels and toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics and Antihypertensives
Reduced efficacy of diuretics and antihypertensive agents.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, epigastric pain, nausea, vomiting, and gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Contraindicated during pregnancy, especially in the third trimester due to potential fetal harm (e.g., premature closure of the ductus arteriosus). Not recommended during lactation as nimesulide may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies, Hospitals
Approval Status
Approved (Hypothetical)
Patent Status
Generic available
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of nimesulide for short-term management of acute pain and fever in pediatric populations, with careful consideration of its safety profile, particularly regarding hepatotoxicity.
Lab Monitoring
- Liver function tests (ALT, AST, ALP, bilirubin) regularly, especially during prolonged use.
- Renal function tests (creatinine, BUN) if renal impairment is a concern.
- Complete blood count (CBC) to monitor for potential hematological effects.
Doctor Notes
- Emphasize short-term use only and lowest effective dose for pediatric patients.
- Advise parents on signs of liver toxicity and GI bleeding.
- Consider patient's overall health and concurrent medications before prescribing.
Patient Guidelines
- Always use this medicine as directed by a healthcare professional.
- Do not exceed the recommended dose or duration of treatment.
- Report any signs of liver problems (e.g., dark urine, yellowing skin/eyes, persistent nausea) immediately.
- Ensure adequate hydration, especially in children with fever.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Not applicable for pediatric patients. For adult users of nimesulide, caution is advised if experiencing dizziness or drowsiness.
Lifestyle Advice
- Ensure the child gets adequate rest.
- Maintain good hydration by encouraging fluid intake.
- Avoid giving other NSAIDs concurrently.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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