Zidimax
Generic Name
Azithromycin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zidimax 250 mg injection | ৳ 70.00 | N/A |
Description
Overview of the medicine
Zidimax 250 mg Injection contains Azithromycin, a macrolide antibiotic used to treat a wide range of bacterial infections. It is administered intravenously for severe infections or when oral therapy is not suitable.
Uses & Indications
Dosage
Adults
500 mg IV as a single daily dose for 1-2 days, followed by oral azithromycin therapy. For PID, 500 mg IV as a single daily dose for 1-2 days, followed by 250 mg oral azithromycin daily to complete a 7-day course.
Elderly
No specific dosage adjustment is recommended, but caution should be exercised in elderly patients with pre-existing cardiac conditions due to potential QTc prolongation.
Renal_impairment
No dosage adjustment is needed for mild to moderate renal impairment (creatinine clearance >10 mL/min). Use with caution in severe renal impairment as data is limited.
How to Take
Administer as an intravenous (IV) infusion over a period of 60 minutes. Do not administer as a rapid intravenous bolus or intramuscular injection. The powder should be reconstituted with sterile water for injection and then diluted in an appropriate intravenous solution before administration.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby blocking the translocation of peptides. This action is primarily bacteriostatic, but can be bactericidal at high concentrations.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved shortly after the end of the 1-hour infusion.
Excretion
Mainly excreted unchanged in bile. A small amount (approximately 6%) is excreted via renal route.
Half life
Terminal elimination half-life is approximately 2-4 days due to extensive tissue distribution.
Absorption
Intravenous administration ensures 100% bioavailability, bypassing gastrointestinal absorption.
Metabolism
Primarily metabolized in the liver to inactive metabolites; however, a significant portion is excreted unchanged.
Side Effects
Contraindications
- •Known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or to any component of the formulation.
- •History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Pimozide
Concomitant use is contraindicated due to risk of QTc prolongation and arrhythmias.
Warfarin
Potentiation of anticoagulant effect, monitor PT/INR.
Nelfinavir
Increased serum concentrations of azithromycin, monitor for adverse effects.
Cyclosporine
Increased cyclosporine levels, monitor cyclosporine concentrations and adjust dose.
Antacids (containing aluminum or magnesium)
May reduce peak plasma concentrations (primarily for oral formulations, but should be considered).
Storage
Store powder vials below 30°C, protected from light and moisture. Do not freeze. Refer to specific manufacturer instructions for reconstituted and diluted solution storage.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves supportive measures, gastric lavage, and symptomatic treatment as required.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Azithromycin is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years for unreconstituted powder. Reconstituted solution stability varies by diluent and storage conditions (e.g., 24 hours at room temperature, 7 days refrigerated).
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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