Zixin
Generic Name
Azithromycin 200 mg/5 mL Suspension
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zixin 200 mg suspension | ৳ 100.00 | N/A |
Description
Overview of the medicine
Zixin 200 mg Suspension is a macrolide antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and certain sexually transmitted diseases.
Uses & Indications
Dosage
Adults
Dosage typically adapted for children for this strength. For adults, usually 500 mg once daily for 3 days or 500 mg on day 1 followed by 250 mg on days 2-5 (may require multiple doses of 200mg/5mL suspension to reach adult dose).
Elderly
No specific dosage adjustment is required for elderly patients with normal renal and hepatic function.
Renal_impairment
No dosage adjustment is necessary for patients with mild to moderate renal impairment (creatinine clearance >40 mL/min).
How to Take
Zixin suspension should be taken orally. It can be taken with or without food. Shake the bottle well before each use. Use the provided measuring device to ensure accurate dosing.
Mechanism of Action
Azithromycin works by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby inhibiting protein synthesis and interfering with bacterial growth and multiplication.
Pharmacokinetics
Onset
Clinical effects usually observed within hours to days, depending on the infection.
Excretion
Primarily excreted unchanged in the bile; a small portion is excreted renally.
Half life
The plasma elimination half-life is long, approximately 2-4 days.
Absorption
Rapidly absorbed after oral administration; bioavailability is approximately 37%.
Metabolism
Limited hepatic metabolism; primarily by N-demethylation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
May increase serum digoxin levels; monitor digoxin levels.
Antacids
Concurrent use with antacids may decrease peak serum concentrations of azithromycin. Take azithromycin at least 2 hours before or 4 hours after antacids.
Warfarin
Increased anticoagulant effect when co-administered; monitor INR closely.
Nelfinavir
Increased azithromycin concentrations; co-administration is not recommended.
QT-prolonging drugs
Increased risk of QT interval prolongation and cardiac arrhythmias (e.g., antiarrhythmics, antipsychotics).
Storage
Store the powder for suspension below 30°C, protected from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) or at room temperature (as per specific product instructions) and discard after the specified shelf life.
Overdose
In case of overdose, gastric lavage and general supportive measures are indicated. Hemodialysis is not effective in removing azithromycin.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Azithromycin is excreted in breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unopened powder for suspension: 2-3 years. Reconstituted suspension: Typically 5-10 days when stored as directed (e.g., refrigerated).
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Off-patent, generic available
WHO Essential Medicine
YesClinical Trials
Azithromycin has been extensively studied in numerous clinical trials for various infectious diseases, demonstrating its efficacy and safety profile in different patient populations.
Lab Monitoring
- Liver function tests (for prolonged use or in patients with pre-existing hepatic impairment)
- Renal function tests (if pre-existing renal impairment)
Doctor Notes
- Emphasize the importance of completing the full prescribed course of antibiotics to prevent recurrence and resistance.
- Counsel patients on potential side effects, particularly gastrointestinal disturbances, and advise them to seek medical attention for severe or persistent symptoms.
- Be aware of potential drug interactions, especially with warfarin, digoxin, and QT-prolonging agents.
Patient Guidelines
- Complete the full course of medication as prescribed, even if symptoms improve.
- Do not share your medication with others.
- Shake the suspension bottle well before each use.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double doses.
Driving Precautions
Azithromycin may cause dizziness or visual disturbances in some patients. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain adequate hydration.
- Ensure sufficient rest during treatment.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.