Zixin
Generic Name
Azithromycin 500 mg tablet
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zixin 500 mg tablet | ৳ 45.00 | ৳ 315.00 |
Description
Overview of the medicine
Zixin 500 mg tablet contains Azithromycin, a macrolide antibiotic used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
For most infections: 500 mg as a single dose on Day 1, followed by 250 mg once daily on Days 2-5, or 500 mg once daily for 3 days. For Chlamydia: 1 gm as a single oral dose.
Elderly
No dosage adjustment is generally required for elderly patients, but caution is advised in those with severe renal or hepatic impairment.
Renal_impairment
No dosage adjustment is necessary for mild to moderate renal impairment. Data for severe renal impairment (GFR < 10 mL/min) is limited; caution is advised.
How to Take
Zixin tablets can be taken with or without food. To ensure complete absorption, it is generally recommended to take it on an empty stomach (at least 1 hour before or 2 hours after a meal).
Mechanism of Action
Azithromycin binds to the 50S ribosomal subunit of susceptible microorganisms, thereby inhibiting protein synthesis and interfering with the assembly of the 50S ribosomal subunit. This leads to the prevention of bacterial growth.
Pharmacokinetics
Onset
Clinical effects usually seen within 24-72 hours, depending on the infection.
Excretion
Mainly excreted unchanged in bile; a small amount is excreted via urine.
Half life
Terminal elimination half-life is 2 to 4 days.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%. Peak plasma concentrations occur within 2-3 hours.
Metabolism
Primarily metabolized in the liver, but a significant portion of the dose is excreted unchanged.
Side Effects
Contraindications
- •Known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of Zixin 500 mg tablet.
- •History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
May increase digoxin levels; monitor digoxin levels.
Antacids
Concurrent administration with antacids containing aluminum or magnesium may reduce the peak plasma concentration of azithromycin.
Warfarin
Increased anticoagulant effect when co-administered; monitor INR closely.
Nelfinavir
Increased azithromycin concentrations reported, no dosage adjustment needed.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are typically an exaggeration of common side effects, such as nausea, vomiting, diarrhea, and abdominal discomfort. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Azithromycin is excreted in human breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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