Zoana
Generic Name
Azithromycin 100 mg/5ml Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zoana 100 mg suspension | ৳ 35.24 | N/A |
Description
Overview of the medicine
Azithromycin is a macrolide antibiotic used to treat various bacterial infections, especially in the respiratory tract, skin, and genitourinary system. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Not typically used in suspension form for adults, but generally 500 mg once daily for 3 days or 500 mg on day 1 followed by 250 mg on days 2-5.
Elderly
No dosage adjustment needed for elderly patients with normal renal and hepatic function.
Renal_impairment
No dosage adjustment necessary for mild to moderate renal impairment (creatinine clearance >10 mL/min). Caution advised in severe impairment.
How to Take
For oral use. Can be taken with or without food. Shake well before use. Use the provided measuring device to ensure accurate dosing.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby blocking translocation of peptides.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-3 hours.
Excretion
Mainly excreted unchanged in bile (approximately 50%) and to a lesser extent via urine (approximately 12%).
Half life
Terminal elimination half-life is 2-4 days.
Absorption
Rapidly absorbed after oral administration; bioavailability is approximately 37%.
Metabolism
Primarily metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Warfarin
Increased anticoagulant effect. Monitor Prothrombin Time (PT)/INR closely.
Nelfinavir
Increased azithromycin serum concentrations. No dosage adjustment needed, but monitor for known side effects.
Antacids (containing aluminum or magnesium)
Decreased peak serum concentrations of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.
P-glycoprotein substrates (e.g., Digoxin, Cyclosporine)
Possible increased concentrations of the P-gp substrate.
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, store at room temperature or refrigerated as per manufacturer's instructions. Do not freeze.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves gastric lavage and general supportive measures as required.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Caution should be exercised when azithromycin is administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Warfarin
Increased anticoagulant effect. Monitor Prothrombin Time (PT)/INR closely.
Nelfinavir
Increased azithromycin serum concentrations. No dosage adjustment needed, but monitor for known side effects.
Antacids (containing aluminum or magnesium)
Decreased peak serum concentrations of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.
P-glycoprotein substrates (e.g., Digoxin, Cyclosporine)
Possible increased concentrations of the P-gp substrate.
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, store at room temperature or refrigerated as per manufacturer's instructions. Do not freeze.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves gastric lavage and general supportive measures as required.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Caution should be exercised when azithromycin is administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unreconstituted powder). Reconstituted suspension: 5-10 days (check specific product instructions).
Availability
Pharmacies, Hospitals
Approval Status
DGDA Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Azithromycin has undergone extensive clinical trials for its approved indications. Ongoing research explores its potential in other areas like anti-inflammatory effects.
Lab Monitoring
- Monitor liver function tests (LFTs) in patients with pre-existing hepatic impairment or prolonged use.
- Monitor Prothrombin Time (PT)/INR if co-administered with warfarin.
Doctor Notes
- Advise patients to complete the full course of therapy to prevent antibiotic resistance.
- Counsel on proper administration of suspension using the provided measuring device.
- Be aware of potential drug interactions, especially with warfarin and antacids.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve.
- Do not share this medication with others.
- Report any unusual or severe side effects to your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose.
Driving Precautions
Azithromycin generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Stay well-hydrated during treatment.
- Avoid alcohol consumption if experiencing gastrointestinal side effects.
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