Zoana
Generic Name
Metronidazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zoana 500 mg tablet | ৳ 10.07 | ৳ 40.28 |
Description
Overview of the medicine
Zoana 500 mg Tablet contains Metronidazole, an antibiotic and antiprotozoal medicine. It is used to treat various bacterial and parasitic infections in different parts of the body.
Uses & Indications
Dosage
Adults
500 mg twice daily for 5-7 days depending on the infection. For specific infections, refer to physician's instructions.
Elderly
No specific dosage adjustment required, but caution is advised due to potential age-related decrease in renal/hepatic function.
Renal_impairment
Dosage adjustment may be necessary in severe renal impairment (CrCl <10 mL/min). Consult a physician.
How to Take
Take the tablet orally with food or milk to minimize stomach upset. Do not chew or crush the tablet.
Mechanism of Action
Metronidazole enters bacterial and parasitic cells, where it is reduced by electron transport proteins to form reactive nitro free radicals. These radicals damage DNA and other biomolecules, leading to cell death.
Pharmacokinetics
Onset
Therapeutic effects usually observed within 24-48 hours.
Excretion
Primarily excreted in the urine (60-80%), with a small amount excreted in feces.
Half life
Approximately 6-11 hours (average 8 hours).
Absorption
Well absorbed orally, peak plasma concentrations typically occur 1-2 hours after administration.
Metabolism
Extensively metabolized in the liver by oxidation and glucuronide conjugation.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or other nitroimidazole derivatives
- First trimester of pregnancy (unless essential)
- Active neurological disease
Drug Interactions
Alcohol
Disulfiram-like reaction (nausea, vomiting, flushing, tachycardia) may occur. Avoid alcohol during and for at least 3 days after treatment.
Lithium
May increase serum lithium levels, leading to lithium toxicity. Monitor lithium levels.
Warfarin
May potentiate the anticoagulant effect of warfarin, increasing bleeding risk. INR monitoring required.
Disulfiram
May cause psychotic reactions. Do not administer metronidazole to patients who have taken disulfiram within the last 14 days.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, ataxia, seizures, and peripheral neuropathy. Management is supportive and symptomatic; no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Consult physician. Avoid during first trimester unless essential. Metronidazole is excreted in breast milk; consider temporary cessation of breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or other nitroimidazole derivatives
- First trimester of pregnancy (unless essential)
- Active neurological disease
Drug Interactions
Alcohol
Disulfiram-like reaction (nausea, vomiting, flushing, tachycardia) may occur. Avoid alcohol during and for at least 3 days after treatment.
Lithium
May increase serum lithium levels, leading to lithium toxicity. Monitor lithium levels.
Warfarin
May potentiate the anticoagulant effect of warfarin, increasing bleeding risk. INR monitoring required.
Disulfiram
May cause psychotic reactions. Do not administer metronidazole to patients who have taken disulfiram within the last 14 days.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, ataxia, seizures, and peripheral neuropathy. Management is supportive and symptomatic; no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Consult physician. Avoid during first trimester unless essential. Metronidazole is excreted in breast milk; consider temporary cessation of breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Multiple clinical trials have established the efficacy and safety of Metronidazole for its approved indications across various patient populations.
Lab Monitoring
- Liver function tests (for prolonged high-dose therapy)
- Complete blood count (rarely, in prolonged therapy, monitor for leukopenia)
- INR monitoring (if co-administered with warfarin)
Doctor Notes
- Advise patients to strictly avoid alcohol during and for at least 3 days after treatment.
- Monitor for signs of peripheral neuropathy, especially with prolonged therapy.
- Caution in patients with severe hepatic impairment; dosage adjustment may be necessary.
- Consider drug interactions, particularly with anticoagulants like warfarin, and monitor INR.
Patient Guidelines
- Complete the full course of medication as prescribed, even if symptoms improve.
- Avoid alcohol during and for at least 3 days after treatment.
- Inform your doctor about any unusual side effects, especially numbness or tingling.
- Take with food to reduce stomach upset.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Zoana-500-mg-tablet may cause dizziness, confusion, or visual disturbances. If affected, do not drive or operate machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids.
- Avoid sexual intercourse during treatment for sexually transmitted infections.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Zoana Brand
Other medicines available under the same brand name
