Zolat
Generic Name
Omeprazole
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zolat 20 mg capsule | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Omeprazole is a proton pump inhibitor (PPI) that reduces gastric acid secretion. It is used to treat conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Usually 20 mg once daily before breakfast for 4-8 weeks for GERD and ulcers. For Zollinger-Ellison syndrome, initial dose is 60 mg once daily, adjusted as needed.
Elderly
No specific dosage adjustment is generally required, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dosage adjustment is necessary for patients with impaired renal function.
How to Take
Take Zolat 20 mg capsule orally, preferably in the morning before a meal. Swallow the capsule whole with water; do not chew, crush, or open it.
Mechanism of Action
Omeprazole irreversibly binds to and inhibits the H+/K+-ATPase (proton pump) in the secretory canaliculi of gastric parietal cells. This action blocks the final step in gastric acid production, leading to a profound and long-lasting reduction in gastric acid secretion.
Pharmacokinetics
Onset
Onset of acid suppression occurs within 1-2 hours. Full therapeutic effect within 4 days of repeated dosing.
Excretion
Approximately 77% of the dose is excreted in the urine as metabolites, and about 18% is excreted in the feces.
Half life
The plasma elimination half-life is short, about 0.5 to 1 hour, but the duration of acid suppression is much longer due to irreversible binding to the proton pump.
Absorption
Rapidly absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached within 0.5 to 3.5 hours. Bioavailability is approximately 30-40%.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to inhibition of CYP2C19.
Methotrexate
Increased and prolonged elevation of methotrexate and/or its metabolite serum levels.
Nelfinavir, Atazanavir
Reduced plasma concentrations of nelfinavir and atazanavir, leading to loss of therapeutic effect.
Warfarin, Diazepam, Phenytoin
Increased plasma concentrations of these drugs, requiring monitoring and potential dose adjustment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, diarrhea, headache, lethargy, confusion, and tachycardia. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Omeprazole is excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to inhibition of CYP2C19.
Methotrexate
Increased and prolonged elevation of methotrexate and/or its metabolite serum levels.
Nelfinavir, Atazanavir
Reduced plasma concentrations of nelfinavir and atazanavir, leading to loss of therapeutic effect.
Warfarin, Diazepam, Phenytoin
Increased plasma concentrations of these drugs, requiring monitoring and potential dose adjustment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, diarrhea, headache, lethargy, confusion, and tachycardia. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Omeprazole is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Omeprazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in various acid-related gastrointestinal disorders, leading to its widespread use.
Lab Monitoring
- Magnesium levels (especially with prolonged use or concomitant use of diuretics)
- Gastrin levels (in suspected Zollinger-Ellison syndrome or for long-term therapy)
- Liver function tests (in patients with hepatic impairment)
Doctor Notes
- Consider alternative diagnostic tests to rule out malignancy before initiating omeprazole therapy for gastric ulcers.
- Monitor for signs of C. difficile infection if diarrhea persists or worsens.
- In elderly patients or those with risk factors, consider periodic monitoring of magnesium and Vitamin B12 levels during prolonged therapy.
- Advise patients about potential rebound acid hypersecretion if treatment is abruptly discontinued.
Patient Guidelines
- Take Zolat 20 mg capsule as prescribed by your doctor.
- Swallow the capsule whole; do not chew, crush, or open it.
- Take it preferably in the morning before your first meal.
- Inform your doctor about all other medications you are taking.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Omeprazole may cause dizziness, visual disturbances, or somnolence. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty, or acidic foods.
- Eat smaller, more frequent meals instead of large ones.
- Avoid lying down immediately after eating.
- Elevate the head of your bed if you suffer from GERD.
- Limit alcohol consumption and stop smoking.
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