Zoledron
Generic Name
Zoledronic Acid
Manufacturer
Novartis (original innovator), various generic manufacturers
Country
Switzerland (Novartis), various countries for generics
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zoledron 5 mg injection | ৳ 5,950.00 | N/A |
Description
Overview of the medicine
Zoledronic acid is a bisphosphonate medication used to treat osteoporosis, Paget's disease of bone, hypercalcemia of malignancy, and bone metastases from solid tumors. It works by slowing down bone loss and strengthening bones.
Uses & Indications
Dosage
Adults
Osteoporosis: 5 mg IV infusion once yearly. Paget's disease: 5 mg IV infusion once. Hypercalcemia of Malignancy: 4 mg IV infusion single dose. Bone metastases/skeletal events: 4 mg IV infusion every 3-4 weeks.
Elderly
No specific dose adjustment required based on age alone, but renal function should be monitored.
Renal_impairment
Dose adjustment or contraindication may apply for severe renal impairment (creatinine clearance < 35 mL/min).
How to Take
Administered as an intravenous infusion over at least 15-30 minutes, ensuring adequate hydration before and after infusion.
Mechanism of Action
Zoledronic acid inhibits osteoclast-mediated bone resorption. It binds to hydroxyapatite crystals in bone and is then internalized by osteoclasts, where it interferes with their mevalonate pathway, leading to osteoclast apoptosis and reduced bone turnover.
Pharmacokinetics
Onset
Initial effects on bone markers observed within days; clinical effects for osteoporosis typically within weeks/months, sustained over years with annual dosing.
Excretion
Primarily excreted unchanged by the kidneys.
Half life
Triphasic elimination, with a long terminal half-life of 146 hours (due to binding to bone).
Absorption
Rapidly distributed to bone and other tissues after IV administration. Minimal systemic absorption occurs from the gastrointestinal tract if taken orally (not the primary route).
Metabolism
Not metabolized in humans.
Side Effects
Contraindications
- •Hypersensitivity to zoledronic acid or other bisphosphonates
- •Hypocalcemia
- •Severe renal impairment (creatinine clearance < 35 mL/min)
- •Pregnancy and lactation
Drug Interactions
Loop Diuretics
May increase risk of hypocalcemia.
Aminoglycosides
May increase risk of hypocalcemia.
Nephrotoxic drugs
Increased risk of renal adverse effects.
Storage
Store at controlled room temperature (20°C-25°C). Do not freeze. Protect from light.
Overdose
Management involves correction of hypocalcemia with intravenous calcium gluconate. Close monitoring of renal function and electrolytes is necessary.
Pregnancy & Lactation
Contraindicated in pregnancy due to potential for fetal harm. Not recommended during lactation as it is unknown if it is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored as recommended.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Off-patent (Generics available)
WHO Essential Medicine
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Global Brand Names
International brand names for this medicine
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