Zosert
Generic Name
Sertraline
Manufacturer
Intas Pharmaceuticals Ltd.
Country
India
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zosert 100 mg tablet | ৳ 10.03 | ৳ 100.30 |
Description
Overview of the medicine
Sertraline is an antidepressant belonging to the Selective Serotonin Reuptake Inhibitors (SSRIs) class. It is used to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD).
Uses & Indications
Dosage
Adults
Typically initiated at 50 mg once daily. Dosage may be increased gradually, if necessary, to a maximum of 200 mg/day.
Elderly
Start with a lower dose (e.g., 25 mg once daily) and adjust cautiously, monitoring for side effects.
Renal_impairment
No dosage adjustment is generally required for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Take orally once daily, with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Sertraline selectively inhibits the reuptake of serotonin (5-HT) into presynaptic neurons, thereby potentiating serotonergic activity in the central nervous system.
Pharmacokinetics
Onset
Therapeutic effects typically begin within 2 to 4 weeks of regular treatment, though some improvement may be seen earlier.
Excretion
Approximately 40-45% excreted in urine and 40-45% in feces, mainly as inactive metabolites.
Half life
Approximately 26 hours (range 22-36 hours) for sertraline and 62-104 hours for its active metabolite, N-desmethylsertraline.
Absorption
Well absorbed orally, with peak plasma concentrations occurring 4.5 to 8.4 hours after administration. Food slightly increases absorption.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19, CYP2B6, CYP2C9, CYP2D6, and CYP3A4 enzymes, to its major active metabolite, N-desmethylsertraline.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping an MAOI.
- Concomitant use with pimozide.
- Hypersensitivity to sertraline or any component of the formulation.
Drug Interactions
Pimozide
Increased pimozide levels and QT prolongation.
Warfarin
Potentiation of anticoagulant effect, leading to increased bleeding risk.
Triptans (e.g., sumatriptan)
Increased risk of serotonin syndrome.
MAOIs (e.g., phenelzine, selegiline)
Increased risk of serotonin syndrome, which can be life-threatening.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of bleeding, especially gastrointestinal bleeding.
Other serotonergic drugs (e.g., tricyclic antidepressants, fentanyl, lithium, tramadol, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, nausea, vomiting, tachycardia, tremor, agitation, dizziness, and rarely, seizures or coma. Management involves supportive and symptomatic treatment. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit outweighs the potential risk to the fetus. Sertraline is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping an MAOI.
- Concomitant use with pimozide.
- Hypersensitivity to sertraline or any component of the formulation.
Drug Interactions
Pimozide
Increased pimozide levels and QT prolongation.
Warfarin
Potentiation of anticoagulant effect, leading to increased bleeding risk.
Triptans (e.g., sumatriptan)
Increased risk of serotonin syndrome.
MAOIs (e.g., phenelzine, selegiline)
Increased risk of serotonin syndrome, which can be life-threatening.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of bleeding, especially gastrointestinal bleeding.
Other serotonergic drugs (e.g., tricyclic antidepressants, fentanyl, lithium, tramadol, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, nausea, vomiting, tachycardia, tremor, agitation, dizziness, and rarely, seizures or coma. Management involves supportive and symptomatic treatment. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit outweighs the potential risk to the fetus. Sertraline is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies
Approval Status
FDA approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established sertraline's efficacy and safety across various psychiatric disorders, including MDD, OCD, panic disorder, PTSD, and social anxiety disorder, supporting its broad therapeutic use.
Lab Monitoring
- Liver function tests (especially in patients with hepatic impairment)
- Serum sodium levels (especially in elderly or patients taking diuretics)
- Electrolyte levels (if serotonin syndrome is suspected)
Doctor Notes
- Closely monitor patients for clinical worsening, suicidality, or unusual behavioral changes, especially at the beginning of treatment or after dose adjustments.
- Educate patients about the importance of adherence and gradual tapering to avoid discontinuation syndrome.
- Assess for potential drug interactions, particularly with other serotonergic agents, MAOIs, and drugs affecting QT interval.
Patient Guidelines
- Take Zosert regularly as prescribed, even if you feel well.
- Do not stop taking Zosert abruptly without consulting your doctor, as this can lead to withdrawal symptoms.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any worsening of depression, suicidal thoughts, or unusual changes in mood or behavior to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.
Driving Precautions
Zosert may cause dizziness, drowsiness, or impaired judgment. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid or limit alcohol consumption while on Zosert.
- Maintain a healthy diet and engage in regular physical activity to support overall well-being.
- Practice stress reduction techniques such as meditation or mindfulness.
- Ensure adequate sleep.
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