Zovia Silver
Generic Name
Ethynodiol Diacetate + Ethinyl Estradiol
Manufacturer
Allergan (now AbbVie)
Country
USA
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zovia silver tablet | ৳ 10.50 | ৳ 315.00 |
Description
Overview of the medicine
Zovia Silver is a combination oral contraceptive used to prevent pregnancy. It contains two female hormones, an estrogen (ethinyl estradiol) and a progestin (ethynodiol diacetate), that work primarily by preventing ovulation.
Uses & Indications
Dosage
Adults
Take one tablet daily at the same time each day for 21 or 28 consecutive days, depending on the pack type. Follow the instructions on the package carefully.
Elderly
Not indicated for postmenopausal women. Contraceptives are generally not recommended for use in women over 35 who smoke.
Renal_impairment
No specific dose adjustment is typically required, but use with caution in patients with severe renal impairment due to potential fluid retention.
How to Take
Take orally with a full glass of water, with or without food, at the same time each day. If taking a 28-day pack, take inert pills on the last 7 days to maintain the routine. Do not skip pills.
Mechanism of Action
This combination oral contraceptive primarily prevents pregnancy by suppressing ovulation. It also causes changes in the cervical mucus, making it more difficult for sperm to reach the uterus, and alters the endometrium, making it less receptive to implantation.
Pharmacokinetics
Onset
Contraceptive protection usually begins after 7 consecutive days of active pill use in the first cycle.
Excretion
Metabolites of both hormones are primarily excreted in urine and feces.
Half life
Ethynodiol diacetate: approximately 5-14 hours (active metabolite). Ethinyl estradiol: approximately 6-20 hours.
Absorption
Both ethynodiol diacetate and ethinyl estradiol are rapidly and well absorbed after oral administration.
Metabolism
Both hormones undergo extensive first-pass metabolism in the liver. Ethynodiol diacetate is rapidly deacetylated to norethindrone. Ethinyl estradiol is metabolized via aromatic hydroxylation.
Side Effects
Contraindications
- •Known or suspected pregnancy
- •History of deep vein thrombosis or pulmonary embolism
- •Cerebrovascular or coronary artery disease
- •Undiagnosed abnormal genital bleeding
- •Known or suspected breast cancer or other estrogen- or progestin-sensitive cancer
- •Liver tumors or active liver disease
- •Uncontrolled hypertension
- •Migraine with aura
Drug Interactions
Rifampin
May reduce contraceptive efficacy; use backup contraception.
St. John's Wort
May induce liver enzymes, reducing contraceptive effectiveness.
Ritonavir-boosted Protease Inhibitors
May alter plasma concentrations of estrogens and progestins; consult prescribing information.
Antibiotics (e.g., Ampicillin, Tetracycline)
Some evidence suggests reduced efficacy, though controversial; backup contraception advised.
Anticonvulsants (e.g., Phenytoin, Carbamazepine)
May reduce contraceptive efficacy; use backup contraception.
Storage
Store at room temperature (20-25°C), away from moisture and light. Keep out of reach of children.
Overdose
Overdose may cause nausea, vomiting, and withdrawal bleeding. Serious adverse effects are not typically expected.
Pregnancy & Lactation
Contraindicated during pregnancy. Not recommended during lactation as it may decrease milk production and affect the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, refer to the package for exact date.
Availability
Pharmacies
Approval Status
FDA Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in