Zunami
Generic Name
Zunamifen Hydrochloride
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zunami 500 mg tablet | ৳ 45.00 | ৳ 225.00 |
Description
Overview of the medicine
Zunami is an analgesic and antipyretic medicine used for the relief of mild to moderate pain and fever. It belongs to the class of Nonsteroidal Anti-inflammatory Drugs (NSAIDs).
Uses & Indications
Dosage
Adults
For adults, take one 500 mg tablet orally every 4-6 hours as needed. Do not exceed 4 tablets (2000 mg) in a 24-hour period.
Elderly
Same as adult dose, but with caution. Close monitoring for adverse effects is recommended.
Renal_impairment
Dose adjustment may be necessary for patients with severe renal impairment. Consult a physician for specific recommendations.
How to Take
Zunami tablets should be swallowed whole with water. It can be taken with or without food. Taking it with food may help reduce gastrointestinal upset.
Mechanism of Action
Zunamifen Hydrochloride primarily acts by inhibiting the synthesis of prostaglandins by blocking cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing inflammation, pain, and fever.
Pharmacokinetics
Onset
Onset of action is typically within 30-60 minutes.
Excretion
Excreted mainly by the kidneys (approximately 60-70% as metabolites) and a small amount via bile.
Half life
The elimination half-life is approximately 2-4 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver through glucuronidation and other oxidative pathways.
Side Effects
Contraindications
- •Hypersensitivity to Zunamifen Hydrochloride or other NSAIDs
- •Active gastric or duodenal ulcer
- •Severe hepatic or renal impairment
- •Third trimester of pregnancy
- •Patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Methotrexate
May increase methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness. In severe cases, gastrointestinal bleeding, acute renal failure, or respiratory depression may occur. Management involves gastric lavage, activated charcoal, and supportive symptomatic therapy.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Use during pregnancy, especially in the third trimester, is generally not recommended due to potential risks to the fetus. Consult a doctor. Small amounts may pass into breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in all pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired
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Global Brand Names
International brand names for this medicine
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