Zycin
Generic Name
Azithromycin 200 mg/5 mL Suspension
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zycin 200 mg suspension | ৳ 95.00 | N/A |
Description
Overview of the medicine
Zycin 200 mg Suspension contains Azithromycin, a macrolide antibiotic, used to treat a wide range of bacterial infections including respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases.
Uses & Indications
Dosage
Adults
For certain adult infections like Chlamydia trachomatis, 1 gram as a single oral dose. For pediatric use (6 months and older): 10 mg/kg orally once daily for 3 days OR 10 mg/kg on Day 1 followed by 5 mg/kg orally once daily on Days 2-5. Max 500 mg per dose. (For most adult indications, tablet form is preferred.)
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with mild to moderate renal impairment (creatinine clearance > 10 mL/min). Caution advised in severe renal impairment.
How to Take
Administer orally, usually once daily. Can be taken with or without food. Shake the suspension well before each use.
Mechanism of Action
Azithromycin works by inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby interfering with the translocation of peptides and inhibiting bacterial growth.
Pharmacokinetics
Onset
Clinical improvement usually observed within 2-3 days of initiation of therapy, depending on the infection.
Excretion
Mainly excreted unchanged in bile, with a small percentage (approx. 6%) excreted in urine.
Half life
The terminal elimination half-life is long, ranging from 2 to 4 days.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%. Peak plasma concentrations are reached in 2-3 hours.
Metabolism
Undergoes extensive hepatic metabolism, primarily by demethylation.
Side Effects
Contraindications
- Known hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
May increase serum concentrations of digoxin. Monitor digoxin levels.
Antacids
Concurrent administration of antacids containing aluminum or magnesium with azithromycin suspension can reduce peak serum levels of azithromycin. Administer azithromycin at least 1 hour before or 2 hours after antacids.
Warfarin
Increased anticoagulant effect when co-administered with azithromycin. Monitor prothrombin time/INR carefully.
Nelfinavir
Increased azithromycin serum concentrations. Monitor for azithromycin side effects.
Storage
Store dry powder at controlled room temperature (20°C to 25°C). After reconstitution, store at controlled room temperature (15°C to 30°C) and discard after 10 days. Do not freeze.
Overdose
Symptoms of overdose are typically characteristic of macrolide antibiotics, including severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment should be symptomatic and supportive, as there is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Azithromycin is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Known hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
May increase serum concentrations of digoxin. Monitor digoxin levels.
Antacids
Concurrent administration of antacids containing aluminum or magnesium with azithromycin suspension can reduce peak serum levels of azithromycin. Administer azithromycin at least 1 hour before or 2 hours after antacids.
Warfarin
Increased anticoagulant effect when co-administered with azithromycin. Monitor prothrombin time/INR carefully.
Nelfinavir
Increased azithromycin serum concentrations. Monitor for azithromycin side effects.
Storage
Store dry powder at controlled room temperature (20°C to 25°C). After reconstitution, store at controlled room temperature (15°C to 30°C) and discard after 10 days. Do not freeze.
Overdose
Symptoms of overdose are typically characteristic of macrolide antibiotics, including severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment should be symptomatic and supportive, as there is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Azithromycin is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years for dry powder. Reconstituted suspension is stable for 10 days when stored at room temperature.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent (generic available)
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety for approved indications, including pediatric populations.
Lab Monitoring
- Liver function tests (LFTs) if prolonged use or in patients with pre-existing hepatic impairment.
- Renal function tests if severe renal impairment is suspected or present.
Doctor Notes
- Emphasize the importance of completing the full course of treatment.
- Counsel patients on potential gastrointestinal side effects and advise taking with food if bothersome.
- Instruct caregivers on proper reconstitution and administration of the suspension, including shaking well before each use.
Patient Guidelines
- Complete the entire prescribed course of medication, even if symptoms improve.
- Do not share this medication with others.
- Report any severe or persistent side effects to your doctor.
- Shake the suspension well before each use and measure with an accurate dosing device.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Azithromycin may cause dizziness. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that azithromycin therapy does not adversely affect them.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid alcohol consumption if it exacerbates gastrointestinal side effects.
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