Zycin
Generic Name
Azithromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zycin 500 mg tablet | ৳ 35.00 | ৳ 210.00 |
Description
Overview of the medicine
Azithromycin is a macrolide antibiotic used to treat various bacterial infections including respiratory tract infections, skin infections, ear infections, and sexually transmitted diseases.
Uses & Indications
Dosage
Adults
Typical regimen: 500 mg once daily for 3 days OR 500 mg as a single dose on day 1, followed by 250 mg once daily for 4 days. For Chlamydia trachomatis: 1g as a single oral dose.
Elderly
No specific dose adjustment is generally required for elderly patients, but monitoring of renal/hepatic function may be prudent.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment (creatinine clearance >10 mL/min). Use with caution in severe renal impairment.
How to Take
Zycin-500 mg tablet can be taken orally, with or without food. For some specific formulations (e.g., oral suspension), it may be recommended to take it without food.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby blocking translation of mRNA. This action is primarily bacteriostatic.
Pharmacokinetics
Onset
Clinical effects usually within 2-3 days, depending on the infection.
Excretion
Primarily excreted unchanged in bile; a small amount is excreted in urine (approx. 6% of dose).
Half life
Terminal elimination half-life is 2-4 days.
Absorption
Rapidly absorbed from the gastrointestinal tract, with approximately 37% bioavailability. Food may decrease absorption of immediate-release capsules, but tablets can generally be taken with or without food.
Metabolism
Partially metabolized in the liver to inactive metabolites, primarily via N-demethylation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Warfarin
May enhance the anticoagulant effect; monitor PT/INR closely.
Nelfinavir
May increase azithromycin serum concentrations. Monitor for side effects.
QT prolonging drugs
Increased risk of QT prolongation and ventricular arrhythmias (e.g., cisapride, pimozide, antiarrhythmics Class IA and III).
Antacids (aluminum or magnesium containing)
May decrease peak plasma levels of azithromycin. Administer azithromycin at least 1 hour before or 2 hours after antacids.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive treatment. Gastric lavage and general supportive measures may be initiated as needed.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus; however, there are no adequate and well-controlled studies in pregnant women. Use in pregnancy only if clearly needed. Azithromycin is excreted in breast milk; use with caution in nursing mothers, weighing the potential benefits against risks to the infant.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Warfarin
May enhance the anticoagulant effect; monitor PT/INR closely.
Nelfinavir
May increase azithromycin serum concentrations. Monitor for side effects.
QT prolonging drugs
Increased risk of QT prolongation and ventricular arrhythmias (e.g., cisapride, pimozide, antiarrhythmics Class IA and III).
Antacids (aluminum or magnesium containing)
May decrease peak plasma levels of azithromycin. Administer azithromycin at least 1 hour before or 2 hours after antacids.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive treatment. Gastric lavage and general supportive measures may be initiated as needed.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus; however, there are no adequate and well-controlled studies in pregnant women. Use in pregnancy only if clearly needed. Azithromycin is excreted in breast milk; use with caution in nursing mothers, weighing the potential benefits against risks to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, depending on specific formulation and manufacturer.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA/DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Azithromycin has undergone extensive clinical trials supporting its efficacy and safety for various bacterial infections. Ongoing research continues to explore its potential uses and optimize treatment regimens.
Lab Monitoring
- Liver function tests (for prolonged therapy or pre-existing hepatic impairment)
- Renal function tests (for severe renal impairment)
Doctor Notes
- Educate patients on the importance of completing the full course to prevent resistance.
- Advise patients to report any signs of allergic reactions or severe gastrointestinal upset immediately.
- Consider drug interactions, especially with warfarin and QT-prolonging agents.
Patient Guidelines
- Complete the full course of medication as prescribed, even if symptoms improve.
- Do not share this medication with others.
- Contact your doctor if you experience severe side effects or if your symptoms worsen or do not improve.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances in some patients; use caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol if it causes stomach upset or worsens side effects.
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