ACT
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| act 80 mg pediatric drop | ৳ 12.31 | N/A |
Description
Overview of the medicine
ACT 80 mg Pediatric Drop is used to relieve mild to moderate pain and reduce fever in infants and young children.
Uses & Indications
Dosage
Adults
Not typically used for adults due to pediatric formulation and low strength; adult formulations are available for appropriate dosing.
Elderly
Not typically used for elderly due to pediatric formulation and low strength; adult formulations are available for appropriate dosing.
Renal_impairment
Caution advised; dose adjustment may be necessary in severe renal impairment. Consult a physician.
How to Take
Oral administration. Administer the prescribed dose using the provided calibrated dropper directly into the child's mouth, or mix with a small amount of water, milk, or juice.
Mechanism of Action
Paracetamol is thought to act primarily in the central nervous system by inhibiting prostaglandin synthesis, which contributes to its analgesic and antipyretic effects.
Pharmacokinetics
Onset
Analgesic and antipyretic effects typically begin within 30-60 minutes.
Excretion
Mainly excreted in urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
Plasma elimination half-life is approximately 1-4 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes.
Metabolism
Primarily metabolized in the liver mainly by conjugation with glucuronic acid and sulfate. A small amount is metabolized via cytochrome P450 to a reactive intermediate (N-acetyl-p-benzoquinone imine or NAPQI), which is normally detoxified by conjugation with glutathione.
Side Effects
Contraindications
- •Hypersensitivity to paracetamol or any other component of the formulation.
- •Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Increased risk of hepatotoxicity, especially with chronic heavy alcohol consumption.
Warfarin and other oral anticoagulants
May enhance anticoagulant effect with prolonged daily use, increasing bleeding risk.
Carbamazepine, Phenobarbital, Phenytoin
May increase the risk of hepatotoxicity.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, sweating, and malaise, potentially followed by liver damage (hepatotoxicity) in 24-48 hours. Seek immediate medical attention. The antidote is N-acetylcysteine, which should be administered as soon as possible.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation when used at recommended doses for short periods. However, always consult a physician before use during these periods.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date. Refer to the expiry date on the packaging.
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved by DGDA
Patent Status
Generic / Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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