Admira MR
Generic Name
Tizanidine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| admira mr 30 mg tablet | ৳ 7.00 | ৳ 70.00 |
| admira mr 60 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Admira MR is a modified-release formulation of Tizanidine, indicated for the relief of muscle spasm.
Uses & Indications
Dosage
Adults
Initially, 2 mg once daily, gradually increasing as needed, not to exceed 6 mg daily.
Elderly
Start with the lowest effective dose and titrate slowly.
Renal_impairment
Use with caution; start with a low dose.
How to Take
Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Tizanidine is an alpha2-adrenergic agonist and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons.
Pharmacokinetics
Onset
Within 1-2 hours.
Excretion
Primarily excreted in the urine as metabolites.
Half life
2-4 hours.
Absorption
Rapidly absorbed; bioavailability is approximately 40%.
Metabolism
Extensively metabolized in the liver via CYP1A2.
Side Effects
Contraindications
- Hypersensitivity to Tizanidine
- Concomitant use with potent CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
Drug Interactions
Fluvoxamine
Significantly increases tizanidine plasma concentrations, potentially leading to severe hypotension.
Ciprofloxacin
Significantly increases tizanidine plasma concentrations, potentially leading to severe hypotension.
Oral Contraceptives
May increase tizanidine plasma concentrations.
Storage
Store below 30°C, protect from light and moisture.
Overdose
Symptoms include drowsiness, bradycardia, hypotension, and respiratory depression. Treatment includes supportive care and symptomatic management.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Tizanidine is excreted in breast milk; caution is advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to Tizanidine
- Concomitant use with potent CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
Drug Interactions
Fluvoxamine
Significantly increases tizanidine plasma concentrations, potentially leading to severe hypotension.
Ciprofloxacin
Significantly increases tizanidine plasma concentrations, potentially leading to severe hypotension.
Oral Contraceptives
May increase tizanidine plasma concentrations.
Storage
Store below 30°C, protect from light and moisture.
Overdose
Symptoms include drowsiness, bradycardia, hypotension, and respiratory depression. Treatment includes supportive care and symptomatic management.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Tizanidine is excreted in breast milk; caution is advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years
Availability
Pharmacies and Drug Stores
Approval Status
DGDA Approved
Patent Status
Off-Patent
Clinical Trials
Several clinical trials have demonstrated the efficacy of tizanidine in reducing muscle spasticity.
Lab Monitoring
- Liver function tests
- Blood pressure monitoring
Doctor Notes
- Start with a low dose and titrate slowly to minimize side effects.
- Monitor for hypotension, especially in elderly patients.
Patient Guidelines
- Avoid alcohol consumption
- Monitor blood pressure regularly
- Do not drive or operate machinery if drowsy
Missed Dose Advice
If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness; avoid driving or operating machinery until effects are known.
Lifestyle Advice
- Maintain a healthy diet
- Engage in light exercise to improve muscle function
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.