Adorex
Generic Name
Escitalopram 10 mg tablet
Manufacturer
Global Pharma Inc.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| adorex 10 mg tablet | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Adorex 10 mg Tablet is a Selective Serotonin Reuptake Inhibitor (SSRI) used to treat major depressive disorder, generalized anxiety disorder, panic disorder, social anxiety disorder, and obsessive-compulsive disorder.
Uses & Indications
Dosage
Adults
Initial dose 10 mg once daily, may be increased to a maximum of 20 mg once daily after at least one week. The therapeutic dose is usually 10 mg.
Elderly
A starting dose of 5 mg once daily is recommended. The maximum recommended dose for elderly patients is 10 mg once daily.
Renal_impairment
No dose adjustment is necessary for mild to moderate renal impairment. Caution is advised in patients with severe renal impairment.
How to Take
Take orally once daily, with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Escitalopram works by increasing the level of serotonin, a natural substance in the brain that helps maintain mental balance, thereby improving mood and reducing anxiety.
Pharmacokinetics
Onset
Therapeutic effects typically begin within 1-2 weeks, but full antidepressant effects may take 2-4 weeks or longer.
Excretion
Excreted through both renal (urine) and fecal routes.
Half life
Approximately 27-32 hours, allowing for once-daily dosing.
Absorption
Well absorbed after oral administration, with peak plasma concentrations occurring after approximately 4 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19, CYP3A4, and CYP2D6 to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to escitalopram or any excipients.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
- Concomitant use with pimozide.
- Congenital long QT syndrome or acquired long QT interval.
Drug Interactions
MAOIs
Risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability, mental status changes).
Pimozide
Increased risk of QT prolongation.
Anticoagulants/NSAIDs
Increased risk of bleeding.
Other serotonergic drugs (e.g., triptans, tramadol, tryptophan, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, tremor, somnolence, nausea, vomiting, tachycardia, and seizures. Management is supportive and symptomatic; ensure adequate airway, oxygenation, and ventilation. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy: Category C. Use only if potential benefit justifies potential risk to the fetus. Exposure in late pregnancy may increase the risk of persistent pulmonary hypertension of the newborn (PPHN). Lactation: Escitalopram is excreted in human breast milk; therefore, caution is advised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to escitalopram or any excipients.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
- Concomitant use with pimozide.
- Congenital long QT syndrome or acquired long QT interval.
Drug Interactions
MAOIs
Risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability, mental status changes).
Pimozide
Increased risk of QT prolongation.
Anticoagulants/NSAIDs
Increased risk of bleeding.
Other serotonergic drugs (e.g., triptans, tramadol, tryptophan, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, tremor, somnolence, nausea, vomiting, tachycardia, and seizures. Management is supportive and symptomatic; ensure adequate airway, oxygenation, and ventilation. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy: Category C. Use only if potential benefit justifies potential risk to the fetus. Exposure in late pregnancy may increase the risk of persistent pulmonary hypertension of the newborn (PPHN). Lactation: Escitalopram is excreted in human breast milk; therefore, caution is advised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2 to 3 years from the date of manufacture, depending on storage conditions.
Availability
Available in retail pharmacies, hospital pharmacies, and online drugstores.
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent (Generic versions available)
Clinical Trials
Escitalopram has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of major depressive disorder and various anxiety disorders in adult populations.
Lab Monitoring
- Routine lab monitoring is generally not required.
- Electrolytes (especially sodium) should be monitored in patients at risk of hyponatremia.
- Liver and kidney function tests may be considered in patients with pre-existing impairment.
Doctor Notes
- Counsel patients on the slow onset of action and the importance of continued adherence to treatment.
- Monitor for suicidal ideation, especially at the initiation of treatment and during dose changes.
- Educate patients about potential withdrawal symptoms if medication is stopped abruptly and advise on gradual tapering.
Patient Guidelines
- Do not stop taking Adorex suddenly, as it can lead to withdrawal symptoms. Consult your doctor for a gradual dose reduction.
- It may take several weeks to feel the full benefits of the medicine. Continue taking it as prescribed.
- Avoid consuming alcohol while on this medication.
- Report any worsening of depression, unusual changes in behavior, or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Adorex may cause dizziness, somnolence, or affect your ability to concentrate. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy lifestyle with regular exercise and a balanced diet.
- Practice stress-reducing techniques such as meditation or yoga.
- Consider psychotherapy or counseling as an adjunct to medication.
- Ensure adequate sleep.
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