Adorex
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| adorex 5 mg suspension | ৳ 28.10 | N/A |
Description
Overview of the medicine
Adorex 5 mg Suspension is an antihistamine containing Fexofenadine Hydrochloride, used to relieve allergy symptoms such as runny nose, sneezing, itchy or watery eyes, and itching of the nose or throat. It is generally well-tolerated and less sedating compared to older antihistamines, making it suitable for pediatric use.
Uses & Indications
Dosage
Adults
Not typically recommended for adults in this specific suspension formulation; adults usually take Fexofenadine tablets.
Elderly
No specific dose adjustment is generally necessary for elderly patients with normal renal function.
Renal_impairment
In adult patients with impaired renal function, a starting dose of 60 mg once daily is recommended. For pediatric patients with impaired renal function, the recommended starting dose is 15 mg (3 mL) once daily for children 6 months to <2 years and 30 mg (6 mL) once daily for children 2 to 11 years.
How to Take
Oral administration. Shake the bottle well before each use. Use the provided measuring spoon or oral syringe to ensure accurate dosing. May be taken with or without food, but avoid fruit juices.
Mechanism of Action
Fexofenadine is a selective peripheral H1-blocker. It works by blocking histamine H1 receptors, thereby preventing the actions of histamine, which is responsible for allergic symptoms like sneezing, itching, and watery eyes.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted in feces (approximately 80%) and urine (approximately 11%) as unchanged drug.
Half life
Approximately 14 hours (ranging from 11-16 hours)
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in 1-3 hours. Absorption is reduced when taken with fruit juices.
Metabolism
Minimally metabolized (approximately 5% of a dose); primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to Fexofenadine Hydrochloride or any of the excipients in the suspension.
Drug Interactions
Erythromycin or Ketoconazole
Concomitant use with these drugs may result in increased Fexofenadine plasma concentrations. However, no difference in the incidence of adverse events has been observed in clinical trials.
Antacids (containing aluminum and magnesium)
May reduce the absorption of Fexofenadine. It is recommended to separate the administration of Fexofenadine and antacids by approximately 2 hours.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Management involves symptomatic and supportive treatment; there is no specific antidote. Gastric lavage or activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted into breast milk in small amounts; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to Fexofenadine Hydrochloride or any of the excipients in the suspension.
Drug Interactions
Erythromycin or Ketoconazole
Concomitant use with these drugs may result in increased Fexofenadine plasma concentrations. However, no difference in the incidence of adverse events has been observed in clinical trials.
Antacids (containing aluminum and magnesium)
May reduce the absorption of Fexofenadine. It is recommended to separate the administration of Fexofenadine and antacids by approximately 2 hours.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Management involves symptomatic and supportive treatment; there is no specific antidote. Gastric lavage or activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted into breast milk in small amounts; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Refer to the expiry date on the product label, typically 24 to 36 months from the manufacturing date when stored correctly. Once opened, use within a specified period (e.g., 28 days) as indicated on the label.
Availability
Pharmacies
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
Clinical Trials
Fexofenadine has undergone extensive clinical trials demonstrating its efficacy and safety in relieving symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria in both adult and pediatric populations. Studies have shown it to be effective with a low incidence of sedation.
Lab Monitoring
- No routine laboratory monitoring is typically required for patients taking Fexofenadine.
Doctor Notes
- Emphasize the importance of accurate dosing with the provided measuring device, especially for pediatric patients.
- Advise parents/caregivers to avoid concomitant administration of Adorex Suspension with fruit juices (grapefruit, orange, apple) to prevent reduced efficacy.
- Counsel on potential interactions with antacids containing aluminum and magnesium, suggesting a 2-hour separation.
Patient Guidelines
- Shake the bottle well for at least 10 seconds before each use.
- Always use the provided measuring device for accurate dosage; household spoons are not accurate.
- Avoid taking this medication with fruit juices (e.g., grapefruit, orange, apple juice).
- Do not exceed the prescribed dose, even if symptoms persist. Consult your doctor if symptoms do not improve.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Fexofenadine is generally non-sedating, but individual responses can vary. If you experience drowsiness or dizziness, avoid driving or operating machinery.
Lifestyle Advice
- Identify and try to avoid specific allergens or triggers that worsen your allergy symptoms.
- Maintain a clean living environment to minimize exposure to dust mites, pet dander, and mold.
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