Adorex
Generic Name
Desloratadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| adorex 5 mg pediatric drop | ৳ 20.07 | N/A |
Description
Overview of the medicine
Adorex 0.5 mg/mL Pediatric Drop contains Desloratadine, a non-sedating antihistamine used to relieve symptoms associated with allergic rhinitis and chronic idiopathic urticaria in children. It provides fast and effective relief from sneezing, runny nose, itchy nose or eyes, congestion, and skin rash.
Uses & Indications
Dosage
Adults
Not applicable for this pediatric formulation. Adult dose for Desloratadine is typically 5 mg once daily.
Elderly
Not applicable for this pediatric formulation. Elderly dose generally follows adult guidelines, with caution for renal/hepatic impairment.
Renal_impairment
For children with severe renal impairment, consult a physician. Consider 1.25 mg (2.5 mL) every other day.
How to Take
Administer orally, with or without food. Use the provided calibrated dropper for accurate dosing. Shake the bottle well before each use.
Mechanism of Action
Desloratadine is a long-acting tricyclic H1-receptor antagonist. It is the major active metabolite of loratadine and acts by selectively antagonizing peripheral H1-histamine receptors, thereby inhibiting the effects of histamine which include vasodilation, increased vascular permeability, and itching.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Excreted in urine (approximately 40%) and feces (approximately 45%) as metabolites.
Half life
Approximately 27 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 3 hours.
Metabolism
Undergoes extensive metabolism, primarily to 3-hydroxydesloratadine, which is also active. Metabolism is primarily by cytochrome P450 enzymes, though the specific isoform involved is not fully identified.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation
- Children under 6 months of age (safety and efficacy not established)
Drug Interactions
Cimetidine
Increased plasma concentrations of desloratadine and 3-hydroxydesloratadine.
Fluoxetine
Increased plasma concentrations of desloratadine and 3-hydroxydesloratadine.
Erythromycin
Increased plasma concentrations of desloratadine and 3-hydroxydesloratadine.
Ketoconazole
Increased plasma concentrations of desloratadine and 3-hydroxydesloratadine.
Storage
Store at controlled room temperature (20°C to 25°C), excursions permitted to 15°C to 30°C. Protect from moisture and light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, somnolence, headache, and tachycardia. In case of overdose, symptomatic and supportive treatment is recommended. Desloratadine is not eliminated by hemodialysis.
Pregnancy & Lactation
Desloratadine is excreted in breast milk. Use during pregnancy and lactation is not recommended for this pediatric formulation. For adult formulations, consult a doctor; generally considered category C for pregnancy.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation
- Children under 6 months of age (safety and efficacy not established)
Drug Interactions
Cimetidine
Increased plasma concentrations of desloratadine and 3-hydroxydesloratadine.
Fluoxetine
Increased plasma concentrations of desloratadine and 3-hydroxydesloratadine.
Erythromycin
Increased plasma concentrations of desloratadine and 3-hydroxydesloratadine.
Ketoconazole
Increased plasma concentrations of desloratadine and 3-hydroxydesloratadine.
Storage
Store at controlled room temperature (20°C to 25°C), excursions permitted to 15°C to 30°C. Protect from moisture and light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, somnolence, headache, and tachycardia. In case of overdose, symptomatic and supportive treatment is recommended. Desloratadine is not eliminated by hemodialysis.
Pregnancy & Lactation
Desloratadine is excreted in breast milk. Use during pregnancy and lactation is not recommended for this pediatric formulation. For adult formulations, consult a doctor; generally considered category C for pregnancy.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date, refer to product label for specific expiry.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies including DGDA (Bangladesh)
Patent Status
Generic available, original patent expired
Clinical Trials
Numerous clinical trials have established the efficacy and safety of desloratadine in treating allergic rhinitis and chronic idiopathic urticaria across various age groups, including pediatric populations. Studies confirm its non-sedating profile and rapid onset of action.
Lab Monitoring
- No specific routine lab monitoring is required for desloratadine at therapeutic doses. In cases of suspected liver dysfunction or overdose, liver function tests may be indicated.
Doctor Notes
- Advise parents on proper use of the calibrated dropper to ensure accurate dosing for pediatric patients.
- Emphasize non-sedating nature, but counsel on potential individual variability.
- Consider renal/hepatic dose adjustment for impaired patients.
Patient Guidelines
- Do not exceed the recommended dose.
- Use the calibrated dropper provided for accurate measurement.
- If symptoms do not improve after a few days, consult a doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Not applicable to infants/children. For adults, desloratadine is generally non-sedating, but individual responses vary. Caution is advised until reaction to the drug is known.
Lifestyle Advice
- Identify and avoid known allergens where possible.
- Maintain good hygiene to reduce exposure to triggers.
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