Afixime
Generic Name
Cefixime 100 mg Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| afixime 100 mg suspension | ৳ 130.00 | N/A |
Description
Overview of the medicine
Afixime 100 mg Suspension contains Cefixime, a third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections including those of the respiratory tract, urinary tract, ear, nose, throat, and uncomplicated gonorrhea.
Uses & Indications
Dosage
Adults
Typically 400 mg daily as a single dose or in two divided doses for adults if suspension is used. Dosage duration depends on infection type.
Elderly
No special dosage adjustment needed unless renal function is severely impaired.
Renal_impairment
Creatinine clearance 21-60 mL/min: 300 mg daily. Creatinine clearance <20 mL/min: 200 mg daily.
How to Take
Administer orally, with or without food. Shake the suspension well before each use. Use a measuring spoon or oral syringe for accurate dosing.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the final transpeptidation step of peptidoglycan synthesis. This leads to the disruption of bacterial cell wall formation and eventual bacterial cell lysis.
Pharmacokinetics
Onset
Peak plasma concentrations usually occur 2-6 hours after administration.
Excretion
Primarily excreted unchanged in the urine (about 50%) and also via biliary excretion.
Half life
Average plasma half-life is 3-4 hours.
Absorption
Approximately 40-50% absorbed orally.
Metabolism
Not extensively metabolized; some metabolism occurs in the liver.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins
- History of serious hypersensitivity reactions to penicillin
Drug Interactions
Nifedipine
May increase cefixime concentrations. No dose adjustment typically required.
Carbamazepine
May increase carbamazepine plasma concentrations. Monitor carbamazepine levels.
Warfarin and other anticoagulants
May increase prothrombin time/INR, increasing risk of bleeding. Close monitoring is advised.
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C).
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Treatment is primarily symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Small amounts of Cefixime are excreted in breast milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins
- History of serious hypersensitivity reactions to penicillin
Drug Interactions
Nifedipine
May increase cefixime concentrations. No dose adjustment typically required.
Carbamazepine
May increase carbamazepine plasma concentrations. Monitor carbamazepine levels.
Warfarin and other anticoagulants
May increase prothrombin time/INR, increasing risk of bleeding. Close monitoring is advised.
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C).
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Treatment is primarily symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Small amounts of Cefixime are excreted in breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 years for dry powder. Reconstituted suspension typically 7-14 days when refrigerated.
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has been extensively studied in various clinical trials demonstrating its efficacy and safety for treating bacterial infections in both pediatric and adult populations.
Lab Monitoring
- Renal function tests (for prolonged therapy or impaired renal function)
- Complete Blood Count (for prolonged therapy)
- Liver function tests (if signs of liver impairment)
Doctor Notes
- Consider patient's history of hypersensitivity to penicillin or cephalosporins before prescribing.
- Advise patients on the importance of completing the full course of treatment.
- Monitor renal function in patients with pre-existing renal impairment.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Do not share this medicine with others.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally, Cefixime does not impair the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
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Global Brand Names
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