Afixime
Generic Name
Cefixime
Manufacturer
Various (e.g., Square Pharmaceuticals Ltd., Beximco Pharmaceuticals Ltd. in Bangladesh)
Country
Bangladesh (or specific country of manufacture)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| afixime 25 mg pediatric drop | ৳ 100.00 | N/A |
Description
Overview of the medicine
Afixime 25 mg Pediatric Drop contains Cefixime, a broad-spectrum cephalosporin antibiotic, used to treat various bacterial infections in children.
Uses & Indications
Dosage
Adults
Not applicable for pediatric drop; adult formulations are available.
Elderly
Not applicable for pediatric drop; elderly dosage should follow adult guidelines with renal adjustment.
Renal_impairment
Dosage adjustment is necessary for severe renal impairment (creatinine clearance < 30 mL/min). Consult physician.
How to Take
Administer orally, preferably with food to reduce gastrointestinal upset. Use the calibrated dropper provided for accurate dosing. Shake the suspension well before each use.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis, leading to bacterial cell lysis and death. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall.
Pharmacokinetics
Onset
Within 2-6 hours (peak plasma concentration)
Excretion
Mainly excreted by the kidneys (approximately 50% unchanged in urine), and some biliary excretion.
Half life
About 3-4 hours
Absorption
Approximately 40-50% orally absorbed. Food can delay absorption but does not significantly alter the extent.
Metabolism
Not extensively metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics.
- Hypersensitivity to penicillin (cross-reactivity can occur).
Drug Interactions
Nifedipine
May increase cefixime peak plasma concentration and AUC.
Carbamazepine
Concomitant administration may increase carbamazepine plasma concentrations.
Warfarin and other anticoagulants
May increase prothrombin time (PT) and INR, increasing the risk of bleeding. Close monitoring is recommended.
Storage
Store the dry powder below 30°C, protected from light and moisture. Store the reconstituted suspension in the refrigerator (2-8°C) and do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics.
- Hypersensitivity to penicillin (cross-reactivity can occur).
Drug Interactions
Nifedipine
May increase cefixime peak plasma concentration and AUC.
Carbamazepine
Concomitant administration may increase carbamazepine plasma concentrations.
Warfarin and other anticoagulants
May increase prothrombin time (PT) and INR, increasing the risk of bleeding. Close monitoring is recommended.
Storage
Store the dry powder below 30°C, protected from light and moisture. Store the reconstituted suspension in the refrigerator (2-8°C) and do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years for dry powder. Reconstituted suspension has a shelf life of 7-14 days when refrigerated.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established cefixime's efficacy and safety in treating various bacterial infections in pediatric and adult populations. Ongoing research continues to monitor resistance patterns.
Lab Monitoring
- Periodic monitoring of renal function, liver function, and complete blood count (CBC) may be advisable during prolonged therapy, especially in patients with pre-existing renal impairment.
Doctor Notes
- Confirm bacterial infection before prescribing; cefixime is not effective against viral infections.
- Advise parents on proper measurement and administration techniques for pediatric drops.
- Educate on completing the full course to prevent antibiotic resistance.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve, to prevent resistance.
- Shake the bottle well before each use.
- Use the measuring dropper provided for accurate dosage.
- Store the reconstituted suspension in the refrigerator and discard after 7 or 14 days as per manufacturer's instructions.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, if dizziness occurs, caution is advised.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Ensure adequate fluid intake.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Afixime Brand
Other medicines available under the same brand name
