Medicine Information

Afixime

Name: Afixime
Brand: Afixime
Rating: 4.5 (117 reviews)

Capsule200 mgAntibiotics (Third Generation Cephalosporins)ATC: J01DD08

Generic Name

Cefixime

Manufacturer

ACI Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
afixime 200 mg capsule	৳ 32.00	৳ 128.00

Description

Overview of the medicine

Afixime 200 mg capsule contains Cefixime, a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections including those of the respiratory tract, urinary tract, ear, and skin.

Uses & Indications

Uncomplicated Urinary Tract Infections (UTIs)

Otitis Media

Pharyngitis and Tonsillitis

Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis

Uncomplicated Gonorrhea

Typhoid Fever

Dosage

Adults

Adults and children over 10 years or weighing more than 50 kg: 200-400 mg orally once daily or in two divided doses (e.g., 200 mg every 12 hours) depending on the severity of the infection. For uncomplicated gonorrhea, a single dose of 400 mg.

Elderly

No dosage adjustment necessary in elderly patients unless there is severe renal impairment.

Renal_impairment

For creatinine clearance 21-60 mL/min: 300 mg daily. For creatinine clearance < 20 mL/min: 200 mg daily. Hemodialysis and CAPD patients: 200 mg daily.

How to Take

Afixime capsules should be taken orally with or without food. It is recommended to take at the same time each day to maintain consistent levels.

Mechanism of Action

Cefixime acts by inhibiting bacterial cell wall synthesis, leading to bacterial lysis and death. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby interfering with the transpeptidation step of peptidoglycan synthesis.

Pharmacokinetics

Onset

Within 2-6 hours (peak plasma concentration)

Excretion

Primarily excreted in urine (about 50% unchanged) and bile.

Half life

Approximately 3-4 hours

Absorption

Approximately 40-50% orally absorbed. Food slightly delays absorption but does not significantly affect the extent.

Metabolism

Limited hepatic metabolism; primarily excreted unchanged.

Side Effects

Contraindications

Known hypersensitivity to Cefixime or other cephalosporin antibiotics
History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics

Drug Interactions

Warfarin

May increase prothrombin time (PT) and International Normalized Ratio (INR), increasing the risk of bleeding. Close monitoring of PT/INR is recommended.

Nifedipine

May increase Cefixime absorption and peak plasma concentration.

Carbamazepine

Cefixime may increase carbamazepine levels. Monitoring of carbamazepine levels is advisable.

Oral Anticoagulants (e.g., Rivaroxaban)

Increased anticoagulant effect, monitor INR.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment is primarily symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Excreted in breast milk in small amounts; caution advised during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per box20 capsules per box

Shelf Life

24-36 months from the date of manufacture

Availability

Available in pharmacies worldwide

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Off-patent (generic available)

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of Cefixime for its approved indications. Ongoing post-marketing surveillance continues to monitor for rare adverse effects.

Lab Monitoring

Renal function tests (e.g., creatinine clearance) in patients with pre-existing renal impairment or during prolonged therapy
Complete blood count (CBC) during prolonged therapy
Liver function tests (LFTs) occasionally

Doctor Notes

Advise patients on the importance of completing the full course of therapy to prevent antibiotic resistance.
Counsel patients on potential side effects, particularly C. difficile diarrhea.
Consider renal function adjustment in elderly or renally impaired patients.

Patient Guidelines

Take the full course of medication as prescribed, even if symptoms improve, to prevent resistance.
Do not skip doses or stop treatment early.
Do not share this medication with others, even if they have similar symptoms.
Inform your doctor if you experience severe diarrhea or allergic reactions.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Cefixime may cause dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how Cefixime affects them.