Ambrox
Generic Name
ambroxol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Ambroxol is a mucolytic agent used to treat respiratory diseases associated with viscid or excessive mucus. It helps to thin and loosen mucus in the airways, making it easier to cough up.
Uses & Indications
Dosage
Adults
30 mg two to three times daily. For sustained release capsules, 75 mg once daily.
Elderly
No specific dosage adjustment is generally required, but caution is advised in patients with severe renal or hepatic impairment.
Renal_impairment
Dosage should be reduced in severe renal impairment. Consultation with a physician is recommended.
How to Take
Oral administration. Tablets can be taken with or without food. Syrup and drops can be mixed with food or drink.
Mechanism of Action
Ambroxol works by stimulating serous glandular secretion and reducing the viscosity of mucus by depolymerizing mucopolysaccharides. It also enhances mucociliary clearance and stimulates pulmonary surfactant production.
Pharmacokinetics
Onset
Onset of action typically occurs within 30 minutes of oral administration.
Excretion
Approximately 90% is excreted renally, mainly as metabolites.
Half life
Plasma elimination half-life is approximately 7-12 hours.
Absorption
Rapid and almost complete absorption from oral administration. Absolute bioavailability is 70-80% due to first-pass metabolism.
Metabolism
Primarily metabolized in the liver to various inactive metabolites, mainly by conjugation.
Side Effects
Contraindications
- Hypersensitivity to ambroxol or any component of the formulation
- History of severe allergic reactions
Drug Interactions
Antibiotics (e.g., amoxicillin, cefuroxime, erythromycin)
Ambroxol can increase the penetration of certain antibiotics into bronchial secretions, potentially enhancing their efficacy.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include nausea, vomiting, diarrhea, and dyspepsia. Management is primarily symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy, especially in the first trimester, only if clearly needed and the potential benefits outweigh the risks. Excreted in breast milk, so use with caution during lactation. Consult a physician.
Side Effects
Contraindications
- Hypersensitivity to ambroxol or any component of the formulation
- History of severe allergic reactions
Drug Interactions
Antibiotics (e.g., amoxicillin, cefuroxime, erythromycin)
Ambroxol can increase the penetration of certain antibiotics into bronchial secretions, potentially enhancing their efficacy.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include nausea, vomiting, diarrhea, and dyspepsia. Management is primarily symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy, especially in the first trimester, only if clearly needed and the potential benefits outweigh the risks. Excreted in breast milk, so use with caution during lactation. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture, depending on the specific formulation and storage conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have demonstrated ambroxol's efficacy in reducing mucus viscosity and improving mucociliary clearance in various respiratory conditions.
Lab Monitoring
- No specific laboratory monitoring is generally required.
Doctor Notes
- Advise patients to maintain adequate hydration.
- Consider underlying respiratory pathology and treat accordingly.
- Monitor for hypersensitivity reactions.
Patient Guidelines
- Take the medicine as directed by your doctor.
- Drink plenty of fluids to help loosen mucus.
- Do not exceed the recommended dose.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Ambroxol is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good hydration by drinking adequate water.
- Avoid smoking as it can worsen respiratory conditions.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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