Take Amdocal 2.5 mg tablet orally, once daily, with or without food. Swallow the tablet whole with water. Do not chew, crush, or break the tablet.

Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. This causes peripheral arterial vasodilation, leading to reduced peripheral vascular resistance and blood pressure reduction. It also increases myocardial oxygen supply in patients with vasospastic angina.

• •Hypersensitivity to amlodipine or other dihydropyridines, or to any of the excipients.
• •Severe hypotension.
• •Cardiogenic shock.
• •Obstruction of the outflow tract of the left ventricle (e.g., high-grade aortic stenosis).
• •Haemodynamically unstable heart failure after acute myocardial infarction.

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose may result in excessive peripheral vasodilation with marked and possibly prolonged systemic hypotension, and reflex tachycardia. Management involves supportive cardiovascular care, including monitoring cardiac and respiratory function, elevation of extremities, and management of circulating fluid volume and urine output. Vasopressors and IV calcium gluconate may be administered.

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Amlodipine is excreted in human milk; lactation is not recommended during treatment.