Amdocal tablet should be taken orally once daily with or without food. It can be taken at any time of day, but it is best to take it at the same time each day.

Amlodipine selectively inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. This causes vasodilation, reducing peripheral vascular resistance, and consequently lowering blood pressure. In angina, it increases myocardial oxygen supply by dilating coronary arteries and reduces myocardial oxygen demand by reducing afterload.

• •Hypersensitivity to Amlodipine or other dihydropyridine derivatives
• •Severe hypotension
• •Cardiogenic shock
• •Clinically significant aortic stenosis
• •Unstable angina (except Prinzmetal's angina)

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose may lead to excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia. Management involves symptomatic treatment and supportive measures. Gastric lavage and activated charcoal may be considered if ingestion is recent. Intravenous calcium gluconate may be beneficial. If hypotension persists, IV fluids and vasopressors may be needed.

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Amlodipine is excreted in human milk; the decision to discontinue breastfeeding or the drug should take into account the importance of the drug to the mother.