Amotid
Generic Name
Amoxicillin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| amotid 500 mg capsule | ৳ 7.50 | ৳ 75.00 |
Description
Overview of the medicine
Amotid 500 mg capsule is a penicillin-class antibiotic used to treat various bacterial infections in the body, such as respiratory tract infections, urinary tract infections, skin infections, and dental infections.
Uses & Indications
Dosage
Adults
Typically 250-500 mg every 8 hours or 500-875 mg every 12 hours, depending on the severity of the infection. Maximum daily dose is 4.5 grams.
Elderly
Generally same as adults, but dose adjustment may be required considering renal function.
Renal_impairment
Dose reduction or increased dosing interval is necessary for creatinine clearance <30 mL/min.
How to Take
Take orally with or without food. Swallow the entire capsule with water; do not break or chew. Complete the full course as prescribed by your doctor.
Mechanism of Action
Amoxicillin works by inhibiting the synthesis of bacterial cell walls. It disrupts the peptidoglycan synthesis of bacteria, which weakens the bacterial cell wall, causing it to rupture and ultimately killing the bacteria.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Primarily excreted unchanged via urine, with a small amount excreted via bile.
Half life
1-1.5 hours
Absorption
Amoxicillin is rapidly and well absorbed from the gastrointestinal tract. Food does not significantly affect its absorption.
Metabolism
Partially metabolized in the liver to inactive metabolites (e.g., penicilloic acid).
Side Effects
Contraindications
- Known allergy to penicillin or any other beta-lactam antibiotics
- Infectious mononucleosis
Drug Interactions
Warfarin
May increase the anticoagulant effect of warfarin, increasing the risk of bleeding.
Allopurinol
Concomitant use with allopurinol may increase the risk of skin rash.
Methotrexate
May decrease methotrexate excretion, increasing its toxicity.
Oral Contraceptives
May decrease the efficacy of some oral contraceptives in certain cases.
Storage
Store below 25°C in a dry and cool place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may cause gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea). Convulsions may occur in patients with impaired renal function. Treatment is symptomatic and supportive. Gastric lavage and hemodialysis may be performed if necessary.
Pregnancy & Lactation
Generally considered safe for use during pregnancy (Pregnancy Category B). Caution should be exercised in breastfeeding mothers, as it can pass into breast milk. Consult a doctor before use.
Side Effects
Contraindications
- Known allergy to penicillin or any other beta-lactam antibiotics
- Infectious mononucleosis
Drug Interactions
Warfarin
May increase the anticoagulant effect of warfarin, increasing the risk of bleeding.
Allopurinol
Concomitant use with allopurinol may increase the risk of skin rash.
Methotrexate
May decrease methotrexate excretion, increasing its toxicity.
Oral Contraceptives
May decrease the efficacy of some oral contraceptives in certain cases.
Storage
Store below 25°C in a dry and cool place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may cause gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea). Convulsions may occur in patients with impaired renal function. Treatment is symptomatic and supportive. Gastric lavage and hemodialysis may be performed if necessary.
Pregnancy & Lactation
Generally considered safe for use during pregnancy (Pregnancy Category B). Caution should be exercised in breastfeeding mothers, as it can pass into breast milk. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Amoxicillin is a well-established antibiotic with extensive clinical trial and research data supporting its efficacy and safety.
Lab Monitoring
- Renal function (creatinine) for prolonged treatment
- Complete blood count (CBC)
Doctor Notes
- Educate patients about antibiotic resistance.
- Be vigilant for any allergic reactions, especially in patients with a history of penicillin allergy.
- Dose adjustment may be required for renal impaired patients.
Patient Guidelines
- Complete the full course as prescribed by your doctor, even if you feel better.
- Do not share your medicine with others.
- Inform your doctor about any history of allergies.
- Can be taken with food to reduce stomach upset.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and follow your regular dosing schedule. Do not take a double dose.
Driving Precautions
Amoxicillin generally does not affect the ability to drive or operate heavy machinery. However, if you experience rare side effects such as dizziness or convulsions, caution should be exercised.
Lifestyle Advice
- Drink plenty of fluids.
- Maintain personal hygiene during the course of medication.
- Avoid unnecessary use of antibiotics.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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